Vaccine and Gene Therapy Institute

Projects

Projects per year 1976 2003 2004 2011 2013 2014 2015 2016 2021

• 1 Active
• 70 Finished
• 253 Not started

Projects per year

Search results

• Finished

  Development of a model for determining the causal relationship between Zika virus infection during pregnancy and fetal microcephaly.

  Streblow, D.

  National Institutes of Health

  9/20/16 → 8/31/18

  Project: Research project

  • Zika Virus Infection 100%
  • Microcephaly 58%
  • Pregnancy 36%
  • Macaca mulatta 17%
  • Viruses 16%

• Delaney AIDS Research Enterprise to Cure HIV

  Picker, L.

  National Institutes of Health

  7/14/16 → 6/30/21

  Project: Research project

  • HIV 100%
  • Acquired Immunodeficiency Syndrome 66%
  • Haplorhini 42%
  • AIDS Vaccines 39%
  • Lymphoid Tissue 33%

• Impact of retroviral infection on non-classical, mycobacteria-specific T cells.

  Hansen, S. & Sacha, J.

  National Institutes of Health

  7/1/16 → 6/30/18

  Project: Research project

  • Tuberculosis 100%
  • Mycobacterium 73%
  • T-Lymphocytes 56%
  • Infections 32%
  • HIV 31%

• International Herpesvirus Workshop

  Nelson, J.

  National Institutes of Health

  7/1/16 → 6/30/17

  Project: Research project

  • Herpesviridae 100%
  • Education 40%
  • Human Herpesvirus 8 23%
  • Human Herpesvirus 2 22%
  • Human Herpesvirus 1 20%

• Investigating the development of AIDs and non-AIDS defining cancers in aged SIV-infected rhesus macaques.

  Wong, S.

  National Institutes of Health

  6/17/16 → 5/31/21

  Project: Research project

  • Simian Immunodeficiency Virus 100%
  • Macaca mulatta 75%
  • HIV Infections 51%
  • Neoplasms 43%
  • HIV 40%

• Consortia for Innovative AIDS Research in Nonhuman Primates

  Picker, L.

  National Institutes of Health

  5/1/16 → 4/30/21

  Project: Research project

  • Vaccines 100%
  • Primates 69%
  • Acquired Immunodeficiency Syndrome 61%
  • T-Lymphocytes 45%
  • Viruses 29%

• Efficacy of Strain 68-1 RhCMV Vectors Expressing 5' Leader Polypeptides

  Hansen, S.

  National Institutes of Health

  4/25/16 → 3/31/20

  Project: Research project

  • AIDS Vaccines 100%
  • Peptides 83%
  • HIV 53%
  • Macaca mulatta 48%
  • Vaccines 34%

• HCMV miRNA Regulation of Secretion and Formation of the Viral Assembly Compartment

  Nelson, J. & Nelson, J.

  National Institutes of Health

  4/1/16 → 3/1/21

  Project: Research project

  • Virus Assembly 100%
  • Cytomegalovirus 95%
  • MicroRNAs 85%
  • Secretory Pathway 62%
  • Cytomegalovirus Infections 44%

• Characterizing the Role of CMV Latency in Solid Organ Transplant Rejection

  Streblow, D.

  National Institutes of Health

  9/2/15 → 2/28/21

  Project: Research project

  • Psychology Rejection 100%
  • Graft Rejection 82%
  • Heart 63%
  • Chemokines 61%
  • Transplants 56%

• International Herpesvirus Workshop

  Nelson, J.

  National Institutes of Health

  7/9/15 → 6/30/16

  Project: Research project

  • Herpesviridae 100%
  • Education 40%
  • Human Herpesvirus 8 23%
  • Human Herpesvirus 2 22%
  • Human Herpesvirus 1 20%

• Heme oxygenase-1 as a tumor factor and therapeutic target for Kaposi sarcoma

  Moses, A.

  National Institutes of Health

  5/1/15 → 4/30/20

  Project: Research project

  • Kaposi's Sarcoma 100%
  • Heme Oxygenase-1 87%
  • Herpesviridae 40%
  • Neoplasms 21%
  • Heme 15%

• A universal MHC-E-restricted T cell vaccine for HIV

  Sacha, J.

  National Institutes of Health

  3/1/15 → 2/28/19

  Project: Research project

  • nef Gene Products 100%
  • T-Lymphocytes 96%
  • AIDS Vaccines 81%
  • Vaccines 47%
  • Alleles 45%

• An unconventional, effector memory T cell vaccine for influenza

  Sacha, J.

  National Institutes of Health

  8/1/14 → 7/31/16

  Project: Research project

  • Influenza Vaccines 100%
  • Human Influenza 80%
  • Vaccines 49%
  • Pandemics 46%
  • T-Lymphocytes 40%

• 32nd Annual Symposium on NHP Models for AIDS

  Sacha, J.

  National Institutes of Health

  8/1/14 → 7/31/15

  Project: Research project

  • Primates 100%
  • animal models 98%
  • vaccines 96%
  • science education 94%
  • public speaking 92%

• International Herpesvirus Workshop

  Nelson, J.

  National Institutes of Health

  7/1/14 → 6/30/15

  Project: Research project

  • Herpesviridae 100%
  • Education 40%
  • Human Herpesvirus 8 23%
  • Human Herpesvirus 2 22%
  • Human Herpesvirus 1 20%

• Graft versus host immunity in SIV clearance following stem cell transplantation.

  Sacha, J.

  National Institutes of Health

  4/15/14 → 3/31/16

  Project: Research project

  • Hematopoietic Stem Cell Transplantation 100%
  • Immunity 57%
  • HIV 56%
  • Transplants 43%
  • Primates 32%

• CMV Vectored Herpes Simplex Vaccine

  Streblow, D.

  National Institutes of Health

  4/10/14 → 3/31/16

  Project: Research project

  • Cytomegalovirus 100%
  • Human Herpesvirus 2 92%
  • Herpes Simplex 63%
  • Vaccines 51%
  • Herpes Simplex Virus Vaccines 49%

• Mechanisms of orthopoxvirus host control and viral immune evasion

  Frueh, K., Fremont, D. H. & Yokoyama, W. M.

  National Institutes of Health

  3/1/14 → 2/28/19

  Project: Research project

  • Cowpox virus 100%
  • Orthopoxvirus 43%
  • Immune Evasion 28%
  • Smallpox 23%
  • Viruses 11%

• Induction of robust T cell response to RRV-LANA

  Wong, S.

  National Institutes of Health

  12/1/13 → 11/30/15

  Project: Research project

  • Rhadinovirus 100%
  • latency-associated nuclear antigen 93%
  • Macaca mulatta 71%
  • Human Herpesvirus 8 36%
  • T-Lymphocytes 32%

• International Herpesvirus Workshop

  Nelson, J.

  National Institutes of Health

  7/15/13 → 6/30/14

  Project: Research project

  • Herpesviridae 100%
  • Education 40%
  • Human Herpesvirus 8 23%
  • Human Herpesvirus 2 22%
  • Human Herpesvirus 1 20%

• Defining non-classical, CMV-induced CD8 T cell responses

  Sacha, J.

  National Institutes of Health

  5/15/13 → 4/30/15

  Project: Research project

  • Macaca 100%
  • T-Lymphocytes 99%
  • AIDS Vaccines 46%
  • Macaca mulatta 37%
  • Vaccines 26%

• An Effector Memory T Cell-Inducing Subunit Vaccine against Malaria

  Frueh, K.

  National Institutes of Health

  2/1/13 → 1/31/16

  Project: Research project

  • Plasmodium knowlesi 100%
  • Sporozoites 67%
  • Subunit Vaccines 60%
  • Malaria 57%
  • Vaccines 47%

• International Herpesvirus Workshop

  Nelson, J.

  National Institutes of Health

  6/1/12 → 5/31/13

  Project: Research project

  • Herpesviridae 100%
  • Education 39%
  • Research Personnel 19%
  • Human Herpesvirus 8 17%
  • Human Herpesvirus 2 16%

• Evaluation of Host miRNAs as Therapeutics against Encephalitogenic Flaviviruses

  Hirsch, A.

  National Institutes of Health

  6/1/12 → 5/31/15

  Project: Research project

  • Flavivirus 100%
  • MicroRNAs 89%
  • Japanese Encephalitis Virus 50%
  • Viruses 25%
  • RNA-Induced Silencing Complex 18%

• Development of an Effector-Memory T Cell AIDS Vaccine

  Picker, L., Axthelm, M., Nelson, J., Kahl, C. A., Frueh, K., Sekaly, R., Barry, P. & Fruh, K.

  National Institutes of Health

  7/15/11 → 6/30/17

  Project: Research project

  • Macaca mulatta 100%
  • AIDS Vaccines 94%
  • Vaccines 69%
  • Cytomegalovirus Vaccines 65%
  • T-Lymphocytes 50%

• Consortium for AIDS Vaccine Research in Nonhuman Primates

  Picker, L., Axthelm, M., Burton, D. R., Johnson, R. P., Shaw, G., Desrosiers, R., Haase, A. T., Sekaly, R. & Barouch, D. H.

  National Institutes of Health

  7/15/11 → 6/30/16

  Project: Research project

  • Macaca mulatta 100%
  • Primates 79%
  • vaccines 48%
  • Infections 48%
  • AIDS Vaccines 40%

• International Herpesvirus Workshop

  Nelson, J.

  National Institutes of Health

  7/1/11 → 6/30/12

  Project: Research project

  • Herpesviridae 100%
  • Education 39%
  • Research Personnel 19%
  • Human Herpesvirus 8 17%
  • Human Herpesvirus 2 16%

• Development and In Vivo Characterization of Safety-Enhanced RhCMV/SIV Vectors

  Picker, L.

  National Institutes of Health

  2/15/11 → 1/31/16

  Project: Research project

  • Macaca mulatta 100%
  • Safety 57%
  • Cytomegalovirus 56%
  • Vaccines 36%
  • AIDS Vaccines 33%

• Efficacy of Oral CMV/SIV Vectors

  Picker, L.

  National Institutes of Health

  12/1/10 → 11/30/16

  Project: Research project

  • Macaca mulatta 100%
  • T-Lymphocytes 49%
  • Vaccines 42%
  • Infections 34%
  • SAIDS Vaccines 27%

• Characterization of Vpu-mediated degradation of BST-2

  Moses, A.

  National Institutes of Health

  5/1/10 → 4/30/15

  Project: Research project

  • HIV-1 100%
  • HIV 97%
  • human BST2 protein 56%
  • Human Immunodeficiency Virus Proteins 53%
  • Antiviral Agents 43%

• Identifying endogenous retrovirus T cell targets in SIV-infected macaques

  Sacha, J.

  National Institutes of Health

  3/3/10 → 2/29/12

  Project: Research project

  • Endogenous Retroviruses 100%
  • T-Lymphocytes 23%
  • Vaccines 17%
  • Macaca mulatta 12%
  • HIV 10%

• Training Program in Virology

  Nelson, J.

  National Institutes of Health

  8/1/09 → 5/31/15

  Project: Research project

  • Virology 100%
  • Education 42%
  • Allergy and Immunology 34%
  • Genomics 32%
  • Cell Biology 28%

• Pacific NorthWest Regional Center of Excellence (PNWRCE)

  Streblow, D., Slifka, M., McWeeney, S., Axthelm, M., Moses, A., Nelson, J., Baric, R., Landfear, S., Nikolich-Zugich, J., Barklis, E., Gale, M., Katze, M., Kawaoka, Y., Bevan, M., Smith, R., Maizels, N., Frueh, K., Labeaud, A. D., Ryman, K., Chanda, S., Galloway, D. A. & Fruh, K.

  National Institutes of Health

  4/20/09 → 2/28/15

  Project: Research project

  • therapeutics 100%
  • vaccines 93%
  • pathogens 90%
  • BBC 89%
  • emerging diseases 86%

• Rejuvenation of the T-cell compartment in aging primates

  Picker, L. & Nikolich-Zugich, J.

  National Institutes of Health

  4/15/09 → 3/31/14

  Project: Research project

  • T-lymphocytes 100%
  • Primates 81%
  • interleukin-7 35%
  • infectious diseases 32%
  • immune system 20%

• The role of CMV secretome in the acceleration of transplant vascular sclerosis

  Nelson, J.

  National Institutes of Health

  5/1/08 → 3/31/13

  Project: Research project

  • Arteriosclerosis 100%
  • Acceleration 75%
  • Transplants 54%
  • Cytomegalovirus 45%
  • Allografts 22%

• Anti-viral IL6 approach to mitigate KSHV-related disease

  Wong, S.

  National Institutes of Health

  5/1/08 → 2/28/14

  Project: Research project

  • Rhadinovirus 100%
  • Human Herpesvirus 8 58%
  • Interleukin-6 41%
  • Simian Immunodeficiency Virus 37%
  • Macaca mulatta 25%

• Modulation of Innate Immune Responses by Cytomegalovirus

  Frueh, K. & Frueh, K.

  National Institutes of Health

  12/15/07 → 11/30/12

  Project: Research project

  • Interferon Regulatory Factor-3 100%
  • Cytomegalovirus 86%
  • Innate Immunity 71%
  • Interferons 49%
  • DNA 15%

• 10th International KSHV and Related Agents Workshop

  Wong, S.

  National Institutes of Health

  7/1/07 → 6/30/08

  Project: Research project

  • public speaking 100%
  • gene therapy 43%
  • Herpesviridae 36%
  • committees 32%
  • planning 28%

• Mechanisms of CMV latency in accelerated vascular disease

  Streblow, D.

  National Institutes of Health

  1/1/06 → 11/30/10

  Project: Research project

  • Arteriosclerosis 100%
  • Cytomegalovirus 83%
  • Vascular Diseases 78%
  • Allografts 72%
  • Transplants 53%

• Role of HIV-1 Vpu in the Regulation of CD40

  Moses, A.

  National Institutes of Health

  11/15/04 → 10/31/10

  Project: Research project

  • HIV-1 100%
  • Endothelial Cells 61%
  • Non-Hodgkin's Lymphoma 52%
  • Acquired Immunodeficiency Syndrome 46%
  • Human Immunodeficiency Virus Proteins 37%

• Validating VIL-6 as a target for KSHV-associated disease

  Wong, S.

  National Institutes of Health

  7/6/04 → 6/30/07

  Project: Research project

  • Human Herpesvirus 8 100%
  • Simian Immunodeficiency Virus 54%
  • Interleukin-6 49%
  • enhanced green fluorescent protein 39%
  • B-Lymphocytes 24%

• The Role of Src Kinase in West Nile Virus Replication

  Nelson, J.

  National Institutes of Health

  7/1/04 → 6/30/07

  Project: Research project

  • src-Family Kinases 98%
  • Virus Replication 70%
  • Viral RNA 41%
  • Life Cycle Stages 41%
  • Viruses 38%

• Evasion of Antigen Presentation by Rhesus CMV

  Frueh, K.

  National Institutes of Health

  7/1/04 → 7/31/17

  Project: Research project

  • Cytomegalovirus 100%
  • Antigen Presentation 67%
  • Major Histocompatibility Complex 55%
  • Viral Interference 51%
  • T-Lymphocytes 38%

• CORE--SCIENTIFIC INTEGRATION AND ADMINISTRATION

  Mori, M., Lewinsohn, D., Axthelm, M., Slifka, M., Picker, L., Frueh, K. & Nikolich-Zugich, J.

  National Institutes of Health

  4/1/04 → 5/31/10

  Project: Research project

  • Primates 100%
  • Biostatistics 79%
  • immunity 68%
  • dendritic cells 66%
  • animal care 64%

• Development of RhCMV Vectors for SIV Infection

  Picker, L.

  National Institutes of Health

  4/1/04 → 8/31/11

  Project: Research project

  • Macaca mulatta 100%
  • Vaccines 93%
  • Humoral Immunity 81%
  • Cellular Immunity 75%
  • Infections 58%

• A Proteomics Research Resource for Integrative Biology

  Nelson, J., Heffron, F., Carter, N., Smith, R., Davis, R. W., Brent, R., Pallavicini, M. G., Udseth, H., Katze, M., Smith, D. J., Anderson, G., Rossie, S., Squier, T. C., Stenoien, D., Thrall, B. D., Klemke, R. L., Warren, H. S., Grobmyer, S., Smallwood, H., Sonenberg, N., Cuschieri, J., Kulkarni, R. N., Moerman, D., Mannick, J., Ginsberg, M. H., Kohwi-Shigematsu, T., Umar, A., Toner, M., Sarwal, M., Esteva, F., Baynes, J., Myers, A., Braeckman, R., Buettner, C., Liu, A., Squier, T. C., Kohwishigematsu, T., Hunzicker-Dunn, M., Cooney, R. N., Belov, M., Katze, M., Smith, D. J., Glass, N. L., Kulkarni, R. N., Stenoien, D., Monroe, M., Davis, R. W., Barr-Gillespie, P. G., Sorger, P. K., Roberts, K., Klein, R. F., Landfear, S. & Bennett, S.

  National Institutes of Health

  9/15/03 → 6/30/13

  Project: Research project

  • proteomics 100%
  • Leishmania 70%
  • purines 64%
  • Effector 33%
  • Protein 25%

• Growth of rheusus cytomegalovirus in macrophages

  Hansen, S.

  National Institutes of Health

  9/1/03 → 8/31/05

  Project: Research project

  • Cytomegalovirus 100%
  • Macrophages 58%
  • Bacterial Artificial Chromosomes 42%
  • Growth 42%
  • Simian Immunodeficiency Virus 39%

• 28th International Herpesvirus Workshop,

  Nelson, J.

  National Institutes of Health

  7/15/03 → 6/30/11

  Project: Research project

  • Herpesviridae 100%
  • Education 49%
  • Research Personnel 15%
  • Human Herpesvirus 8 15%
  • Human Herpesvirus 2 15%

• Identifying cellular genes as anti-HIV drug targets

  Moses, A.

  National Institutes of Health

  6/1/03 → 5/31/04

  Project: Research project

  • Anti-HIV Agents 100%
  • Genes 49%
  • HIV 40%
  • HIV Infections 30%
  • Human Genome 24%

• Role of memory T cell dynamics in SIV infection

  Picker, L.

  National Institutes of Health

  1/1/03 → 6/30/18

  Project: Research project

  • T-Lymphocytes 100%
  • Macaca mulatta 89%
  • Infections 75%
  • Interleukin-15 45%
  • Homeostasis 29%