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Yoon-Jae Cho

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19992023

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  • 2023

    Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma

    Chapman, O. S., Luebeck, J., Sridhar, S., Wong, I. T. L., Dixit, D., Wang, S., Prasad, G., Rajkumar, U., Pagadala, M. S., Larson, J. D., He, B. J., Hung, K. L., Lange, J. T., Dehkordi, S. R., Chandran, S., Adam, M., Morgan, L., Wani, S., Tiwari, A. & Guccione, C. & 28 others, Lin, Y., Dutta, A., Lo, Y. Y., Juarez, E., Robinson, J. T., Korshunov, A., Michaels, J. E. A., Cho, Y. J., Malicki, D. M., Coufal, N. G., Levy, M. L., Hobbs, C., Scheuermann, R. H., Crawford, J. R., Pomeroy, S. L., Rich, J. N., Zhang, X., Chang, H. Y., Dixon, J. R., Bagchi, A., Deshpande, A. J., Carter, H., Fraenkel, E., Mischel, P. S., Wechsler-Reya, R. J., Bafna, V., Mesirov, J. P. & Chavez, L., Dec 2023, In: Nature genetics. 55, 12, p. 2189-2199 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    12 Scopus citations
  • 2022

    Immune Checkpoint Inhibition as Single Therapy for Synchronous Cancers Exhibiting Hypermutation: An IRRDC Study

    Henderson, J. J., Das, A., Morgenstern, D. A., Sudhaman, S., Bianchi, V., Chung, J., Negm, L., Edwards, M., Kram, D. E., Osborn, M., Hawkins, C., Bouffet, E., Cho, Y. J. & Tabori, U., 2022, In: JCO Precision Oncology. 6, e2100286.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    16 Scopus citations

  • MRI Radiogenomics of Pediatric Medulloblastoma: A Multicenter Study

    Zhang, M., Wong, S. W., Wright, J. N., Wagner, M. W., Toescu, S., Han, M., Tam, L. T., Zhou, Q., Ahmadian, S. S., Shpanskaya, K., Lummus, S., Lai, H., Eghbal, A., Radmanesh, A., Nemelka, J., Harward, S., Malinzak, M., Laughlin, S., Perreault, S. & Braun, K. R. M. & 19 others, Lober, R. M., Cho, Y. J., Ertl-Wagner, B., Ho, C. Y., Mankad, K., Vogel, H., Cheshier, S. H., Jacques, T. S., Aquilina, K., Fisher, P. G., Taylor, M., Poussaint, T., Vitanza, N. A., Grant, G. A., Pfister, S., Thompson, E., Jaju, A., Ramaswamy, V. & Yeom, K. W., Aug 2022, In: RADIOLOGY. 304, 2, p. 406-416 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    45 Scopus citations
  • 2021

    Clinical Outcomes and Patient-Matched Molecular Composition of Relapsed Medulloblastoma

    Kumar, R., Smith, K. S., Deng, M., Terhune, C., Robinson, G. W., Orr, B. A., Liu, A. P. Y., Lin, T., Billups, C. A., Chintagumpala, M., Bowers, D. C., Hassall, T. E., Hansford, J. R., Khuong-Quang, D. A., Crawford, J. R., Bendel, A. E., Gururangan, S., Schroeder, K., Bouffet, E. & Bartels, U. & 44 others, Fisher, M. J., Cohn, R., Partap, S., Kellie, S. J., McCowage, G., Paulino, A. C., Rutkowski, S., Fleischhack, G., Dhall, G., Klesse, L. J., Leary, S., Nazarian, J., Kool, M., Wesseling, P., Ryzhova, M., Zheludkova, O., Golanov, A. V., McLendon, R. E., Packer, R. J., Dunham, C., Hukin, J., Fouladi, M., Faria, C. C., Pimentel, J., Walter, A. W., Jabado, N., Cho, Y. J., Perreault, S., Croul, S. E., Zapotocky, M., Hawkins, C., Tabori, U., Taylor, M. D., Pfister, S. M., Klimo, P., Boop, F. A., Ellison, D. W., Merchant, T. E., Onar-Thomas, A., Korshunov, A., Jones, D. T. W., Gajjar, A., Ramaswamy, V. & Northcott, P. A., Mar 1 2021, In: Journal of Clinical Oncology. 39, 7, p. 807-821 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    48 Scopus citations

  • Mechanisms of targeted therapy resistance in a pediatric glioma driven by ETV6-NTRK3 fusion

    Keddy, C., Neff, T., Huan, J., Nickerson, J. P., Beach, C. Z., Akkari, Y., Ji, J., Moore, S., Nazemi, K. J., Corless, C. L., Beadling, C., Woltjer, R., Cho, Y. J., Wood, M. D. & Davare, M. A., Dec 2021, In: Cold Spring Harbor Molecular Case Studies. 7, 5, a006109.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    10 Scopus citations
  • 2020

    Functional precision medicine identifies new therapeutic candidates for medulloblastoma

    Rusert, J. M., Juarez, E. F., Brabetz, S., Jensen, J., Garancher, A., Chau, L. Q., Tacheva-Grigorova, S. K., Wahab, S., Udaka, Y. T., Finlay, D., Seker-Cin, H., Reardon, B., Grobner, S., Serrano, J., Ecker, J., Qi, L., Kogiso, M., Du, Y., Baxter, P. A. & Henderson, J. J. & 20 others, Berens, M. E., Vuori, K., Milde, T., Cho, Y. J., Li, X. N., Olson, J. M., Reyes, I., Snuderl, M., Wong, T. C., Dimmock, D. P., Nahas, S. A., Malicki, D., Crawford, J. R., Levy, M. L., van Allen, E. M., Pfister, S. M., Tamayo, P., Kool, M., Mesirov, J. P. & Wechsler-Reya, R. J., Dec 1 2020, In: Cancer Research. 80, 23, p. 5393-5407 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    39 Scopus citations

  • Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma

    Garancher, A., Suzuki, H., Haricharan, S., Chau, L. Q., Masihi, M. B., Rusert, J. M., Norris, P. S., Carrette, F., Romero, M. M., Morrissy, S. A., Skowron, P., Cavalli, F. M. G., Farooq, H., Ramaswamy, V., Jones, S. J. M., Moore, R. A., Mungall, A. J., Ma, Y., Thiessen, N. & Li, Y. & 20 others, Morcavallo, A., Qi, L., Kogiso, M., Du, Y., Baxter, P., Henderson, J. J., Crawford, J. R., Levy, M. L., Olson, J. M., Cho, Y. J., Deshpande, A. J., Li, X. N., Chesler, L., Marra, M. A., Wajant, H., Becher, O. J., Bradley, L. M., Ware, C. F., Taylor, M. D. & Wechsler-Reya, R. J., Jul 1 2020, In: Nature Neuroscience. 23, 7, p. 842-853 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    38 Scopus citations
  • 2019

    BMI1 is a therapeutic target in recurrent medulloblastoma

    Bakhshinyan, D., Venugopal, C., Adile, A. A., Garg, N., Manoranjan, B., Hallett, R., Wang, X., Mahendram, S., Vora, P., Vijayakumar, T., Subapanditha, M., Singh, M., Kameda-Smith, M. M., Qazi, M., McFarlane, N., Mann, A., Ajani, O. A., Yarascavitch, B., Ramaswamy, V. & Farooq, H. & 18 others, Morrissy, S., Cao, L., Sydorenko, N., Baiazitov, R., Du, W., Sheedy, J., Weetall, M., Moon, Y. C., Lee, C. S., Kwiecien, J. M., Delaney, K. H., Doble, B., Cho, Y. J., Mitra, S., Kaplan, D., Taylor, M. D., Davis, T. W. & Singh, S. K., Mar 7 2019, In: Oncogene. 38, 10, p. 1702-1716 15 p.

    Research output: Contribution to journal › Article › peer-review

    22 Scopus citations

  • Casein kinase 2 inhibition sensitizes medulloblastoma to temozolomide

    Nitta, R. T., Bolin, S., Luo, E., Solow-Codero, D. E., Samghabadi, P., Purzner, T., Aujla, P. S., Nwagbo, G., Cho, Y. J. & Li, G., Oct 17 2019, In: Oncogene. 38, 42, p. 6867-6879 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    20 Scopus citations

  • Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

    Huang, M., Tailor, J., Zhen, Q., Gillmor, A. H., Miller, M. L., Weishaupt, H., Chen, J., Zheng, T., Nash, E. K., McHenry, L. K., An, Z., Ye, F., Takashima, Y., Clarke, J., Ayetey, H., Cavalli, F. M. G., Luu, B., Moriarity, B. S., Ilkhanizadeh, S. & Chavez, L. & 18 others, Yu, C., Kurian, K. M., Magnaldo, T., Sevenet, N., Koch, P., Pollard, S. M., Dirks, P., Snyder, M. P., Largaespada, D. A., Cho, Y. J., Phillips, J. J., Swartling, F. J., Morrissy, A. S., Kool, M., Pfister, S. M., Taylor, M. D., Smith, A. & Weiss, W. A., Sep 5 2019, In: Cell Stem Cell. 25, 3, p. 433-446.e7

    Research output: Contribution to journal › Article › peer-review

    Open Access
    58 Scopus citations

  • MR imaging-based radiomic signatures of distinct molecular subgroups of medulloblastoma

    Iv, M., Zhou, M., Shpanskaya, K., Perreault, S., Wang, Z., Tranvinh, E., Lanzman, B., Vajapeyam, S., Vitanza, N. A., Fisher, P. G., Cho, Y. J., Laughlin, S., Ramaswamy, V., Taylor, M. D., Cheshier, S. H., Grant, G. A., Young Poussaint, T., Gevaert, O. & Yeom, K. W., Jan 1 2019, In: American Journal of Neuroradiology. 40, 1, p. 154-161 8 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    101 Scopus citations
  • 2018

    A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases

    Garzia, L., Kijima, N., Morrissy, A. S., De Antonellis, P., Guerreiro-Stucklin, A., Holgado, B. L., Wu, X., Wang, X., Parsons, M., Zayne, K., Manno, A., Kuzan-Fischer, C., Nor, C., Donovan, L. K., Liu, J., Qin, L., Garancher, A., Liu, K. W., Mansouri, S. & Luu, B. & 34 others, Thompson, Y. Y., Ramaswamy, V., Peacock, J., Farooq, H., Skowron, P., Shih, D. J. H., Li, A., Ensan, S., Robbins, C. S., Cybulsky, M., Mitra, S., Ma, Y., Moore, R., Mungall, A., Cho, Y. J., Weiss, W. A., Chan, J. A., Hawkins, C. E., Massimino, M., Jabado, N., Zapotocky, M., Sumerauer, D., Bouffet, E., Dirks, P., Tabori, U., Sorensen, P. H. B., Brastianos, P. K., Aldape, K., Jones, S. J. M., Marra, M. A., Woodgett, J. R., Wechsler-Reya, R. J., Fults, D. W. & Taylor, M. D., Feb 22 2018, In: Cell. 172, 5, p. 1050-1062.e14

    Research output: Contribution to journal › Article › peer-review

    Open Access
    74 Scopus citations

  • Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma

    Bolin, S., Borgenvik, A., Persson, C. U., Sundström, A., Qi, J., Bradner, J. E., Weiss, W. A., Cho, Y. J., Weishaupt, H. & Swartling, F. J., May 1 2018, In: Oncogene. 37, 21, p. 2850-2862 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    69 Scopus citations

  • Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma

    Purzner, T., Purzner, J., Buckstaff, T., Cozza, G., Gholamin, S., Rusert, J. M., Hartl, T. A., Sanders, J., Conley, N., Ge, X., Langan, M., Ramaswamy, V., Ellis, L., Litzenburger, U., Bolin, S., Theruvath, J., Nitta, R., Qi, L., Li, X. N. & Li, G. & 7 others, Taylor, M. D., Wechsler-Reya, R. J., Pinna, L. A., Cho, Y. J., Fuller, M. T., Elias, J. E. & Scott, M. P., Sep 11 2018, In: Science signaling. 11, 547, eaau5147.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    61 Scopus citations

  • Notch1 regulates the initiation of metastasis and self-renewal of Group 3 medulloblastoma

    Kahn, S. A., Wang, X., Nitta, R. T., Gholamin, S., Theruvath, J., Hutter, G., Azad, T. D., Wadi, L., Bolin, S., Ramaswamy, V., Esparza, R., Liu, K. W., Edwards, M., Swartling, F. J., Sahoo, D., Li, G., Wechsler-Reya, R. J., Reimand, J., Cho, Y. J. & Taylor, M. D. & 3 others, Weissman, I. L., Mitra, S. S. & Cheshier, S. H., Dec 1 2018, In: Nature communications. 9, 1, 4121.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    33 Scopus citations
  • 2017

    A first-in-class twist1 inhibitor with activity in oncogene-driven lung cancer

    Yochum, Z. A., Cades, J., Mazzacurati, L., Neumann, N. M., Khetarpal, S. K., Chatterjee, S., Wang, H., Attar, M. A., Huang, E. H. B., Chatley, S. N., Nugent, K., Somasundaram, A., Engh, J. A., Ewald, A. J., Cho, Y. J., Rudin, C. M., Tran, P. T. & Burns, T. F., Dec 2017, In: Molecular Cancer Research. 15, 12, p. 1764-1776 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    73 Scopus citations

  • Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors

    Gholamin, S., Mitra, S. S., Feroze, A. H., Liu, J., Kahn, S. A., Zhang, M., Esparza, R., Richard, C., Ramaswamy, V., Remke, M., Volkmer, A. K., Willingham, S., Ponnuswami, A., McCarty, A., Lovelace, P., Storm, T. A., Schubert, S., Hutter, G., Narayanan, C. & Chu, P. & 14 others, Raabe, E. H., Harsh, G., Taylor, M. D., Monje, M., Cho, Y. J., Majeti, R., Volkmer, J. P., Fisher, P. G., Grant, G., Steinberg, G. K., Vogel, H., Edwards, M., Weissman, I. L. & Cheshier, S. H., Mar 15 2017, In: Science translational medicine. 9, 381, eaaf2968.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    343 Scopus citations

  • Functional validation of the oncogenic cooperativity and targeting potential of tuberous sclerosis mutation in medulloblastoma using a MYC-amplified model cell line

    Henderson, J. J., Wagner, J. P., Hofmann, N. E., Eide, C. A., Cho, Y. J., Druker, B. J. & Davare, M. A., Oct 2017, In: Pediatric Blood and Cancer. 64, 10, e26553.

    Research output: Contribution to journal › Article › peer-review

    2 Scopus citations

  • Pediatric high-grade glioma: Biologically and clinically in need of new thinking

    Jones, C., Karajannis, M. A., Jones, D. T. W., Kieran, M. W., Monje, M., Baker, S. J., Becher, O. J., Cho, Y. J., Gupta, N., Hawkins, C., Hargrave, D., Haas-Kogan, D. A., Jabado, N., Li, X. N., Mueller, S., Nicolaides, T., Packer, R. J., Persson, A. I., Phillips, J. J. & Simonds, E. F. & 4 others, Stafford, J. M., Tang, Y., Pfister, S. M. & Weiss, W. A., 2017, In: Neuro-Oncology. 19, 2, p. 153-161 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    290 Scopus citations

  • Pediatric oncology enters an era of precision medicine

    Seibel, N. L., Janeway, K., Allen, C. E., Chi, S. N., Cho, Y. J., Glade Bender, J. L., Kim, A. R., Laetsch, T. W., Irwin, M. S., Takebe, N., Tricoli, J. V. & Parsons, D. W., May 2017, In: Current problems in cancer. 41, 3, p. 194-200 7 p.

    Research output: Contribution to journal › Article › peer-review

    42 Scopus citations

  • The whole-genome landscape of medulloblastoma subtypes

    Northcott, P. A., Buchhalter, I., Morrissy, A. S., Hovestadt, V., Weischenfeldt, J., Ehrenberger, T., Gröbner, S., Segura-Wang, M., Zichner, T., Rudneva, V. A., Warnatz, H. J., Sidiropoulos, N., Phillips, A. H., Schumacher, S., Kleinheinz, K., Waszak, S. M., Erkek, S., Jones, D. T. W., Worst, B. C. & Kool, M. & 67 others, Zapatka, M., Jäger, N., Chavez, L., Hutter, B., Bieg, M., Paramasivam, N., Heinold, M., Gu, Z., Ishaque, N., Jäger-Schmidt, C., Imbusch, C. D., Jugold, A., Hübschmann, D., Risch, T., Amstislavskiy, V., Gonzalez, F. G. R., Weber, U. D., Wolf, S., Robinson, G. W., Zhou, X., Wu, G., Finkelstein, D., Liu, Y., Cavalli, F. M. G., Luu, B., Ramaswamy, V., Wu, X., Koster, J., Ryzhova, M., Cho, Y. J., Pomeroy, S. L., Herold-Mende, C., Schuhmann, M., Ebinger, M., Liau, L. M., Mora, J., McLendon, R. E., Jabado, N., Kumabe, T., Chuah, E., Ma, Y., Moore, R. A., Mungall, A. J., Mungall, K. L., Thiessen, N., Tse, K., Wong, T., Jones, S. J. M., Witt, O., Milde, T., Von Deimling, A., Capper, D., Korshunov, A., Yaspo, M. L., Kriwacki, R., Gajjar, A., Zhang, J., Beroukhim, R., Fraenkel, E., Korbel, J. O., Brors, B., Schlesner, M., Eils, R., Marra, M. A., Pfister, S. M., Taylor, M. D. & Lichter, P., Jul 19 2017, In: Nature. 547, 7663, p. 311-317 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    802 Scopus citations
  • 2016

    Divergent clonal selection dominates medulloblastoma at recurrence

    Morrissy, A. S., Garzia, L., Shih, D. J. H., Zuyderduyn, S., Huang, X., Skowron, P., Remke, M., Cavalli, F. M. G., Ramaswamy, V., Lindsay, P. E., Jelveh, S., Donovan, L. K., Wang, X., Luu, B., Zayne, K., Li, Y., Mayoh, C., Thiessen, N., Mercier, E. & Mungall, K. L. & 118 others, Ma, Y., Tse, K., Zeng, T., Shumansky, K., Roth, A. J. L., Shah, S., Farooq, H., Kijima, N., Holgado, B. L., Lee, J. J. Y., Matan-Lithwick, S., Liu, J., Mack, S. C., Manno, A., Michealraj, K. A., Nor, C., Peacock, J., Qin, L., Reimand, J., Rolider, A., Thompson, Y. Y., Wu, X., Pugh, T., Ally, A., Bilenky, M., Butterfield, Y. S. N., Carlsen, R., Cheng, Y., Chuah, E., Corbett, R. D., Dhalla, N., He, A., Lee, D., Li, H. I., Long, W., Mayo, M., Plettner, P., Qian, J. Q., Schein, J. E., Tam, A., Wong, T., Birol, I., Zhao, Y., Faria, C. C., Pimentel, J., Nunes, S., Shalaby, T., Grotzer, M., Pollack, I. F., Hamilton, R. L., Li, X. N., Bendel, A. E., Fults, D. W., Walter, A. W., Kumabe, T., Tominaga, T., Collins, V. P., Cho, Y. J., Hoffman, C., Lyden, D., Wisoff, J. H., Garvin, J. H., Stearns, D. S., Massimi, L., Schüller, U., Sterba, J., Zitterbart, K., Puget, S., Ayrault, O., Dunn, S. E., Tirapelli, D. P. C., Carlotti, C. G., Wheeler, H., Hallahan, A. R., Ingram, W., MacDonald, T. J., Olson, J. J., Van Meir, E. G., Lee, J. Y., Wang, K. C., Kim, S. K., Cho, B. K., Pietsch, T., Fleischhack, G., Tippelt, S., Ra, Y. S., Bailey, S., Lindsey, J. C., Clifford, S. C., Eberhart, C. G., Cooper, M. K., Packer, R. J., Massimino, M., Garre, M. L., Bartels, U., Tabori, U., Hawkins, C. E., Dirks, P., Bouffet, E., Rutka, J. T., Wechsler-Reya, R. J., Weiss, W. A., Collier, L. S., Dupuy, A. J., Korshunov, A., Jones, D. T. W., Kool, M., Northcott, P. A., Pfister, S. M., Largaespada, D. A., Mungall, A. J., Moore, R. A., Jabado, N., Bader, G. D., Jones, S. J. M., Malkin, D., Marra, M. A. & Taylor, M. D., Jan 21 2016, In: Nature. 529, 7586, p. 351-357 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    262 Scopus citations

  • FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma

    Suryo Rahmanto, A., Savov, V., Brunner, A., Bolin, S., Weishaupt, H., Malyukova, A., Rosén, G., Čančer, M., Hutter, S., Sundström, A., Kawauchi, D., Jones, D. T. W., Spruck, C., Taylor, M. D., Cho, Y. J., Pfister, S. M., Kool, M., Korshunov, A., Swartling, F. J. & Sangfelt, O., Oct 17 2016, In: EMBO Journal. 35, 20, p. 2192-2212 21 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    62 Scopus citations

  • HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma

    Pei, Y., Liu, K. W., Wang, J., Garancher, A., Tao, R., Esparza, L. A., Maier, D. L., Udaka, Y. T., Murad, N., Morrissy, S., Seker-Cin, H., Brabetz, S., Qi, L., Kogiso, M., Schubert, S., Olson, J. M., Cho, Y. J., Li, X. N., Crawford, J. R. & Levy, M. L. & 4 others, Kool, M., Pfister, S. M., Taylor, M. D. & Wechsler-Reya, R. J., Mar 14 2016, In: Cancer Cell. 29, 3, p. 311-323 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    207 Scopus citations

  • IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma

    Svalina, M. N., Kikuchi, K., Abraham, J., Lal, S., Davare, M. A., Settelmeyer, T. P., Young, M. C., Peckham, J. L., Cho, Y. J., Michalek, J. E., Hernandez, B. S., Berlow, N. E., Jackson, M., Guillaume, D. J., Selden, N. R., Bigner, D. D., Nazemi, K. J., Green, S. C., Corless, C. L. & Gultekin, S. & 4 others, Mansoor, A., Rubin, B. P., Woltjer, R. & Keller, C., Jun 3 2016, In: Scientific Reports. 6, 27012.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    20 Scopus citations

  • Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress

    Oh, S., Flynn, R. A., Floor, S. N., Purzner, J., Martin, L., Do, B. T., Schubert, S., Vaka, D., Morrissy, S., Li, Y., Kool, M., Hovestadt, V., Jones, D. T. W., Northcott, P. A., Risch, T., Warnatz, H. J., Yaspo, M. L., Adams, C. M., Leib, R. D. & Breese, M. & 8 others, Marra, M. A., Malkin, D., Lichter, P., Doudna, J. A., Pfister, S. M., Taylor, M. D., Chang, H. Y. & Cho, Y. J., May 10 2016, In: Oncotarget. 7, 19, p. 28169-28182 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    62 Scopus citations

  • Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype

    Phoenix, T. N., Patmore, D. M., Boop, S., Boulos, N., Jacus, M. O., Patel, Y. T., Roussel, M. F., Finkelstein, D., Goumnerova, L., Perreault, S., Wadhwa, E., Cho, Y. J., Stewart, C. F. & Gilbertson, R. J., Apr 11 2016, In: Cancer Cell. 29, 4, p. 508-522 15 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    250 Scopus citations

  • PI-3K inhibitors preferentially target CD15+ cancer stem cell population in SHH driven medulloblastoma

    Singh, A. R., Joshi, S., Zulcic, M., Alcaraz, M., Garlich, J. R., Morales, G. A., Cho, Y. J., Bao, L., Levy, M. L., Newbury, R., Malicki, D., Messer, K., Crawford, J. & Durden, D. L., Mar 2016, In: PloS one. 11, 3, e0150836.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    23 Scopus citations

  • Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

    Thompson, E. M., Hielscher, T., Bouffet, E., Remke, M., Luu, B., Gururangan, S., McLendon, R. E., Bigner, D. D., Lipp, E. S., Perreault, S., Cho, Y. J., Grant, G., Kim, S. K., Lee, J. Y., Rao, A. A. N., Giannini, C., Li, K. K. W., Ng, H. K., Yao, Y. & Kumabe, T. & 87 others, Tominaga, T., Grajkowska, W. A., Perek-Polnik, M., Low, D. C. Y., Seow, W. T., Chang, K. T. E., Mora, J., Pollack, I. F., Hamilton, R. L., Leary, S., Moore, A. S., Ingram, W. J., Hallahan, A. R., Jouvet, A., Fèvre-Montange, M., Vasiljevic, A., Faure-Conter, C., Shofuda, T., Kagawa, N., Hashimoto, N., Jabado, N., Weil, A. G., Gayden, T., Wataya, T., Shalaby, T., Grotzer, M., Zitterbart, K., Sterba, J., Kren, L., Hortobágyi, T., Klekner, A., László, B., Pócza, T., Hauser, P., Schüller, U., Jung, S., Jang, W. Y., French, P. J., Kros, J. M., van Veelen, M. L. C., Massimi, L., Leonard, J. R., Rubin, J. B., Vibhakar, R., Chambless, L. B., Cooper, M. K., Thompson, R. C., Faria, C. C., Carvalho, A., Nunes, S., Pimentel, J., Fan, X., Muraszko, K. M., López-Aguilar, E., Lyden, D., Garzia, L., Shih, D. J. H., Kijima, N., Schneider, C., Adamski, J., Northcott, P. A., Kool, M., Jones, D. T. W., Chan, J. A., Nikolic, A., Garre, M. L., Van Meir, E. G., Osuka, S., Olson, J. J., Jahangiri, A., Castro, B. A., Gupta, N., Weiss, W. A., Moxon-Emre, I., Mabbott, D. J., Lassaletta, A., Hawkins, C. E., Tabori, U., Drake, J., Kulkarni, A., Dirks, P., Rutka, J. T., Korshunov, A., Pfister, S. M., Packer, R. J., Ramaswamy, V. & Taylor, M. D., Apr 1 2016, In: The Lancet Oncology. 17, 4, p. 484-495 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    286 Scopus citations
  • 2015

    A five-gene hedgehog signature developed as a patient preselection tool for hedgehog inhibitor therapy in medulloblastoma

    Shou, Y., Robinson, D. M., Amakye, D. D., Rose, K. L., Cho, Y. J., Ligon, K. L., Sharp, T., Haider, A. S., Bandaru, R., Ando, Y., Geoerger, B., Doz, F., Ashley, D. M., Hargrave, D. R., Casanova, M., Tawbi, H. A., Rodon, J., Thomas, A. L., Mita, A. C. & MacDonald, T. J. & 1 others, Kieran, M. W., Feb 1 2015, In: Clinical Cancer Research. 21, 3, p. 585-593 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    49 Scopus citations

  • EphrinB1 expression is dysregulated and promotes oncogenic signaling in medulloblastoma

    McKinney, N., Yuan, L., Zhang, H., Liu, J., Cho, Y. J., Rushing, E., Schniederjan, M. & MacDonald, T. J., Jan 2015, In: Journal of Neuro-Oncology. 121, 1, p. 109-118 10 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    9 Scopus citations

  • Medulloblastoma subgroups remain stable across primary and metastatic compartments

    Wang, X., Dubuc, A. M., Ramaswamy, V., Mack, S., Gendoo, D. M. A., Remke, M., Wu, X., Garzia, L., Luu, B., Cavalli, F., Peacock, J., López, B., Skowron, P., Zagzag, D., Lyden, D., Hoffman, C., Cho, Y. J., Eberhart, C., MacDonald, T. & Li, X. N. & 9 others, Van Meter, T., Northcott, P. A., Haibe-Kains, B., Hawkins, C., Rutka, J. T., Bouffet, E., Pfister, S. M., Korshunov, A. & Taylor, M. D., Feb 18 2015, In: Acta Neuropathologica. 129, 3, p. 449-457 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    77 Scopus citations

  • Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction

    Fogal, V., Babic, I., Chao, Y., Pastorino, S., Mukthavaram, R., Jiang, P., Cho, Y. J., Pingle, S. C., Crawford, J. R., Piccioni, D. E. & Kesari, S., 2015, In: Oncotarget. 6, 2, p. 1157-1170 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    41 Scopus citations

  • Proteomic profiling of high risk medulloblastoma reveals functional biology

    Staal, J. A., Lau, L. S., Zhang, H., Ingram, W. J., Hallahan, A. R., Northcott, P. A., Pfister, S. M., Wechsler-Reya, R. J., Rusert, J. M., Taylor, M. D., Cho, Y. J., Packer, R. J., Brown, K. J. & Rood, B. R., 2015, In: Oncotarget. 6, 16, p. 14584-14595 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    19 Scopus citations
  • 2014

    Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5

    Mora-Blanco, E. L., Mishina, Y., Tillman, E. J., Cho, Y. J., Thom, C. S., Pomeroy, S. L., Shao, W. & Roberts, C. W. M., Feb 13 2014, In: Oncogene. 33, 7, p. 933-938 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    68 Scopus citations

  • Arhgap36-dependent activation of Gli transcription factors

    Rack, P. G., Ni, J., Payumo, A. Y., Nguyen, V., Crapster, J. A., Hovestadt, V., Kool, M., Jones, D. T. W., Mich, J. K., Firestone, A. J., Pfister, S. M., Cho, Y. J. & Chen, J. K., 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 30, p. 11061-11066 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    35 Scopus citations

  • BET bromodomain inhibition of MYC-amplified medulloblastoma

    Bandopadhayay, P., Bergthold, G., Nguyen, B., Schubert, S., Gholamin, S., Tang, Y., Bolin, S., Schumacher, S. E., Zeid, R., Masoud, S., Yu, F., Vue, N., Gibson, W. J., Paolella, B. R., Mitra, S. S., Cheshier, S. H., Qi, J., Liu, K. W., Wechsler-Reya, R. & Weiss, W. A. & 5 others, Swartling, F. J., Kieran, M. W., Bradner, J. E., Beroukhim, R. & Cho, Y. J., 2014, In: Clinical Cancer Research. 20, 4, p. 912-925 14 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    278 Scopus citations

  • Cytogenetic prognostication within medulloblastoma subgroups

    Shih, D. J. H., Northcott, P. A., Remke, M., Korshunov, A., Ramaswamy, V., Kool, M., Luu, B., Yao, Y., Wang, X., Dubuc, A. M., Garzia, L., Peacock, J., Mack, S. C., Wu, X., Rolider, A., Morrissy, A. S., Cavalli, F. M. G., Jones, D. T. W., Zitterbart, K. & Faria, C. C. & 73 others, Schüller, U., Kren, L., Kumabe, T., Tominaga, T., Ra, Y. S., Garami, M., Hauser, P., Chan, J. A., Robinson, S., Bognár, L., Klekner, A., Saad, A. G., Liau, L. M., Albrecht, S., Fontebasso, A., Cinalli, G., De Antonellis, P., Zollo, M., Cooper, M. K., Thompson, R. C., Bailey, S., Lindsey, J. C., Di Rocco, C., Massimi, L., Michiels, E. M. C., Scherer, S. W., Phillips, J. J., Gupta, N., Fan, X., Muraszko, K. M., Vibhakar, R., Eberhart, C. G., Fouladi, M., Lach, B., Jung, S., Wechsler-Reya, R. J., Fèvre-Montange, M., Jouvet, A., Jabado, N., Pollack, I. F., Weiss, W. A., Lee, J. Y., Cho, B. K., Kim, S. K., Wang, K. C., Leonard, J. R., Rubin, J. B., De Torres, C., Lavarino, C., Mora, J., Cho, Y. J., Tabori, U., Olson, J. M., Gajjar, A., Packer, R. J., Rutkowski, S., Pomeroy, S. L., French, P. J., Kloosterhof, N. K., Kros, J. M., Van Meir, E. G., Clifford, S. C., Bourdeaut, F., Delattre, O., Doz, F. F., Hawkins, C. E., Malkin, D., Grajkowska, W. A., Perek-Polnik, M., Bouffet, E., Rutka, J. T., Pfister, S. M. & Taylor, M. D., Mar 20 2014, In: Journal of Clinical Oncology. 32, 9, p. 886-896 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    252 Scopus citations

  • Dasatinib suppression of medulloblastoma survival and migration is markedly enhanced by combining treatment with the aurora kinase inhibitor AT9283

    Petersen, W., Liu, J., Yuan, L., Zhang, H., Schneiderjan, M., Cho, Y. J. & MacDonald, T. J., Nov 1 2014, In: Cancer Letters. 354, 1, p. 68-76 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    17 Scopus citations

  • Diffusion-weighted MRI derived apparent diffusion coefficient identifies prognostically distinct subgroups of pediatric diffuse intrinsic pontine glioma

    Lober, R. M., Cho, Y. J., Tang, Y., Barnes, P. D., Edwards, M. S., Vogel, H., Fisher, P. G., Monje, M. & Yeom, K. W., Mar 2014, In: Journal of Neuro-Oncology. 117, 1, p. 175-182 8 p.

    Research output: Contribution to journal › Article › peer-review

    64 Scopus citations

  • Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition

    Tang, Y., Gholamin, S., Schubert, S., Willardson, M. I., Lee, A., Bandopadhayay, P., Bergthold, G., Masoud, S., Nguyen, B., Vue, N., Balansay, B., Yu, F., Oh, S., Woo, P., Chen, S., Ponnuswami, A., Monje, M., Atwood, S. X., Whitson, R. J. & Mitra, S. & 9 others, Cheshier, S. H., Qi, J., Beroukhim, R., Tang, J. Y., Wechsler-Reya, R., Oro, A. E., Link, B. A., Bradner, J. E. & Cho, Y. J., Jul 2014, In: Nature medicine. 20, 7, p. 732-740 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    264 Scopus citations

  • Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

    MacK, S. C., Witt, H., Piro, R. M., Gu, L., Zuyderduyn, S., Stütz, A. M., Wang, X., Gallo, M., Garzia, L., Zayne, K., Zhang, X., Ramaswamy, V., Jäger, N., Jones, D. T. W., Sill, M., Pugh, T. J., Ryzhova, M., Wani, K. M., Shih, D. J. H. & Head, R. & 69 others, Remke, M., Bailey, S. D., Zichner, T., Faria, C. C., Barszczyk, M., Stark, S., Seker-Cin, H., Hutter, S., Johann, P., Bender, S., Hovestadt, V., Tzaridis, T., Dubuc, A. M., Northcott, P. A., Peacock, J., Bertrand, K. C., Agnihotri, S., Cavalli, F. M. G., Clarke, I., Nethery-Brokx, K., Creasy, C. L., Verma, S. K., Koster, J., Wu, X., Yao, Y., Milde, T., Sin-Chan, P., Zuccaro, J., Lau, L., Pereira, S., Castelo-Branco, P., Hirst, M., Marra, M. A., Roberts, S. S., Fults, D., Massimi, L., Cho, Y. J., Van Meter, T., Grajkowska, W., Lach, B., Kulozik, A. E., Von Deimling, A., Witt, O., Scherer, S. W., Fan, X., Muraszko, K. M., Kool, M., Pomeroy, S. L., Gupta, N., Phillips, J., Huang, A., Tabori, U., Hawkins, C., Malkin, D., Kongkham, P. N., Weiss, W. A., Jabado, N., Rutka, J. T., Bouffet, E., Korbel, J. O., Lupien, M., Aldape, K. D., Bader, G. D., Eils, R., Lichter, P., Dirks, P. B., Pfister, S. M., Korshunov, A. & Taylor, M. D., 2014, In: Nature. 506, 7489, p. 445-450 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    497 Scopus citations

  • Expression quantitative trait loci and receptor pharmacology implicate Arg1 and the GABA-A receptor as therapeutic targets in neuroblastoma

    Hackett, C. S., Quigley, D. A., Wong, R. A., Chen, J., Cheng, C., Song, Y. K., Wei, J. S., Pawlikowska, L., Bao, Y., Goldenberg, D. D., Nguyen, K., Clay Gustafson, W., Rallapalli, S. K., Cho, Y. J., Cook, J. M., Kozlov, S., Mao, J. H., Van Dyke, T., Kwok, P. Y. & Khan, J. & 3 others, Balmain, A., Fan, Q. W. & Weiss, W. A., 2014, In: Cell Reports. 9, 3, p. 1034-1046 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    27 Scopus citations

  • Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

    Kool, M., Jones, D. T. W., Jäger, N., Northcott, P. A., Pugh, T. J., Hovestadt, V., Piro, R. M., Esparza, L. A., Markant, S. L., Remke, M., Milde, T., Bourdeaut, F., Ryzhova, M., Sturm, D., Pfaff, E., Stark, S., Hutter, S., Sxeker-Cin, H., Johann, P. & Bender, S. & 56 others, Schmidt, C., Rausch, T., Shih, D., Reimand, J., Sieber, L., Wittmann, A., Linke, L., Witt, H., Weber, U. D., Zapatka, M., König, R., Beroukhim, R., Bergthold, G., Van Sluis, P., Volckmann, R., Koster, J., Versteeg, R., Schmidt, S., Wolf, S., Lawerenz, C., Bartholomae, C. C., Von Kalle, C., Unterberg, A., Herold-Mende, C., Hofer, S., Kulozik, A. E., Von Deimling, A., Scheurlen, W., Felsberg, J., Reifenberger, G., Hasselblatt, M., Crawford, J. R., Grant, G. A., Jabado, N., Perry, A., Cowdrey, C., Croul, S., Zadeh, G., Korbel, J. O., Doz, F., Delattre, O., Bader, G. D., McCabe, M. G., Collins, V. P., Kieran, M. W., Cho, Y. J., Pomeroy, S. L., Witt, O., Brors, B., Taylor, M. D., Schüller, U., Korshunov, A., Eils, R., Wechsler-Reya, R. J., Lichter, P. & Pfister, S. M., Mar 17 2014, In: Cancer Cell. 25, 3, p. 393-405 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    620 Scopus citations

  • Medulloblastoma Down under 2013: A report from the third annual meeting of the International Medulloblastoma Working Group

    Gottardo, N. G., Hansford, J. R., McGlade, J. P., Alvaro, F., Ashley, D. M., Bailey, S., Baker, D. L., Bourdeaut, F., Cho, Y. J., Clay, M., Clifford, S. C., Cohn, R. J., Cole, C. H., Dallas, P. B., Downie, P., Doz, F., Ellison, D. W., Endersby, R., Fisher, P. G. & Hassall, T. & 31 others, Heath, J. A., Hii, H. L., Jones, D. T. W., Junckerstorff, R., Kellie, S., Kool, M., Kotecha, R. S., Lichter, P., Laughton, S. J., Lee, S., McCowage, G., Northcott, P. A., Olson, J. M., Packer, R. J., Pfister, S. M., Pietsch, T., Pizer, B., Pomeroy, S. L., Remke, M., Robinson, G. W., Rutkowski, S., Schoep, T., Shelat, A. A., Stewart, C. F., Sullivan, M., Taylor, M. D., Wainwright, B., Walwyn, T., Weiss, W. A., Williamson, D. & Gajjar, A., Feb 2014, In: Acta Neuropathologica. 127, 2, p. 189-201 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    94 Scopus citations

  • MRI surrogates for molecular subgroups of medulloblastoma

    Perreault, S., Ramaswamy, V., Achrol, A. S., Chao, K., Liu, T. T., Shih, D., Remke, M., Schubert, S., Bouffet, E., Fisher, P. G., Partap, S., Vogel, H., Taylor, M. D., Cho, Y. J. & Yeom, K. W., Jul 2014, In: American Journal of Neuroradiology. 35, 7, p. 1263-1269 7 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    247 Scopus citations

  • WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma

    Zhukova, N., Ramaswamy, V., Remke, M., Martin, D. C., Castelo-Branco, P., Zhang, C. H., Fraser, M., Tse, K., Poon, R., Shih, D. J. H., Baskin, B., Ray, P. N., Bouffet, E., Dirks, P., von Bueren, A. O., Pfaff, E., Korshunov, A., Jones, D. T. W., Northcott, P. A. & Kool, M. & 40 others, Pugh, T. J., Pomeroy, S. L., Cho, Y. J., Pietsch, T., Gessi, M., Rutkowski, S., Bognár, L., Cho, B. K., Eberhart, C. G., Conter, C. F., Fouladi, M., French, P. J., Grajkowska, W. A., Gupta, N., Hauser, P., Jabado, N., Vasiljevic, A., Jung, S., Kim, S. K., Klekner, A., Kumabe, T., Lach, B., Leonard, J. R., Liau, L. M., Massimi, L., Pollack, I. F., Ra, Y. S., Rubin, J. B., Van Meir, E. G., Wang, K. C., Weiss, W. A., Zitterbart, K., Bristow, R. G., Alman, B., Hawkins, C. E., Malkin, D., Clifford, S. C., Pfister, S. M., Taylor, M. D. & Tabori, U., Jan 27 2014, In: Acta Neuropathologica Communications. 2, 1, 174.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    37 Scopus citations

  • α5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth

    Sengupta, S., Weeraratne, S. D., Sun, H., Phallen, J., Rallapalli, S. K., Teider, N., Kosaras, B., Amani, V., Pierre-Francois, J., Tang, Y., Nguyen, B., Yu, F., Schubert, S., Balansay, B., Mathios, D., Lechpammer, M., Archer, T. C., Tran, P., Reimer, R. J. & Cook, J. M. & 4 others, Lim, M., Jensen, F. E., Pomeroy, S. L. & Cho, Y. J., Apr 2014, In: Acta Neuropathologica. 127, 4, p. 593-603 11 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    40 Scopus citations
  • 2013

    BAF complexes facilitate decatenation of DNA by topoisomerase IIα

    Dykhuizen, E. C., Hargreaves, D. C., Miller, E. L., Cui, K., Korshunov, A., Kool, M., Pfister, S., Cho, Y. J., Zhao, K. & Crabtree, G. R., May 30 2013, In: Nature. 497, 7451, p. 624-627 4 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    211 Scopus citations

  • Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1

    Ramkissoon, L. A., Horowitz, P. M., Craig, J. M., Ramkissoon, S. H., Rich, B. E., Schumacher, S. E., McKenna, A., Lawrence, M. S., Bergthold, G., Brastianos, P. K., Tabak, B., Ducar, M. D., Van Hummelen, P., MacConaill, L. E., Pouissant-Young, T., Cho, Y. J., Taha, H., Mahmoud, M., Bowers, D. C. & Margraf, L. & 17 others, Tabori, U., Hawkins, C., Packer, R. J., Hill, D. A., Pomeroy, S. L., Eberhart, C. G., Dunn, I. F., Goumnerova, L., Getz, G., Chan, J. A., Santagata, S., Hahn, W. C., Stiles, C. D., Ligon, A. H., Kieran, M. W., Beroukhim, R. & Ligon, K. L., May 14 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 20, p. 8188-8193 6 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    189 Scopus citations