Project: Research project

    Project Details


    The importance of maintaining dietary calcium intake and normal
    calcium metabolism for optimal regulation of arterial pressure in
    humans and experimental models has been demonstrated by us and
    other investigators. Recent reports have suggested that low
    dietary calcium intake and disturbances in maternal calcium
    metabolism may be associated with an increases in blood pressure
    during late gestation. These factors may be associated with an
    increase in the risk of developing pregnancy-induced hypertension.
    To explore this hypothesis, during year 1 of this proposal dietary
    calcium intake and biochemical markers of calcium metabolism
    will be assessed and compared during the 3rd trimester in 40
    women with pregnancy-induced hypertension and 40 normotensive
    matched controls to determine if significant differences exist in
    dietary calcium intake and metabolic indices of calcium between
    these two groups. From 4-6 weeks postpartum, blood pressure,
    calcium intake, and the same biochemical markers will be
    reassessed in both lactating and non-lactating women. During
    years 2-5, we will prospectively assess blood pressure, nutrient
    intake, and markers of calcium metabolism in a group of 300
    clinically normal women from 24 to 36 weeks of pregnancy.
    Nutrient intake, including dietary calcium, will be assessed during
    gestation weeks 24, 28, 32, 36, and the postpartum period using 3-
    day food records and 24-hour dietary recalls. Concomitantly,
    serum measures of calcium metabolism will be assessed including
    serum total and ionized calcium, parathyroid hormone, calcitonin,
    and 1,25(OH)2 vitamin D3 concentrations and serum magnesium,
    phosphorus, sodium, and potassium concentrations. During weeks
    24 and 32, urinary excretion of sodium, calcium, magnesium,
    potassium, phosphorus, cAMP, and creatinine will be measured.
    Blood pressure will be measured at every prenatal visit and
    postpartum. Measures of infant growth and blood pressure will be
    assessed at 1, 6, and 12 months of age to determine if maternal
    dietary calcium intake, calcium metabolism, and/or maternal
    gestational blood pressure exert long-term influences on infant
    development and blood pressure. The results of this study will
    provide further insights into the possible role of dietary calcium
    intake and maternal calcium homeostasis in the regulation of
    blood pressure in normal pregnancy and pregnancy complicated by
    hypertension. These observations should provide data to construct
    testable hypotheses for further research into the putative
    mechanisms of calcium's influence in pregnancy-induced
    Effective start/end date9/30/875/31/92


    • National Institutes of Health


    • Medicine(all)


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