Project: Research project

    Project Details


    During my years of training and practice, I have become convinced that a
    significant amount of scientific work has to be done in the field of
    clinical medicine to make its practice more objective and thus ultimately
    more useful. One of the areas that has interested me is regional
    myocardial perfusion and function and the inadequacy of coronary
    angiography in determining the significance of coronary stenosis. During
    my work with myocardial contrast agents, I became interested in their
    potential use for determining absolute regional myocardial perfusion. In
    addition, if the current limitations inherent in the quantitative
    assessment of regional myocardial function could be overcome,
    two-dimensional echocardiography would become an ideal and readily
    available tool for simultaneously assessing regional myocardial perfusion
    and function. This proposal deals in detail with what I think has to be investigated in
    order for myocardial contrast echocardiography to become a suitable
    modality for measuring regional perfusion and function. The relationship
    between contrast effect and blood flow has to be established; the effect of
    size and distribution of microbubbles on myocardial contrast effect has to
    be determined; the fate of microbubbles in the microvasculature has to be
    studied and the effect of these bubbles on the microvasculature has to be
    documented; the agent producing the least reactive hyperemic response has
    to be identified and its toxicity in intact animal and man studied.
    Finally, preliminary work has to be attempted in humans demonstrating
    significant advantages over currently available techniques of measuring
    myocardial blood flow. After developing a new algorithm for measuring
    regional myocardial function, studies involving flow-function relationships
    have to be performed.
    Effective start/end date7/1/866/30/91


    • National Institutes of Health


    • Medicine(all)


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