Project Details
Description
DESCRIPTION (provided by applicant)
This is an application to become a Member of the NIEHS Toxicogenomics Research
Consortium. The application originates from the synergistic fusion of two
components of the Oregon Health Sciences University (OHSU), the resulting
entity working in close cooperation with the Massachusetts General Hospital
(MGH) at Harvard University. Leadership of this research program and the
Toxicology Research Core Project (TRCP) is located in the OHSU Center for
Research on Occupational and Environmental Toxicology (CROET), a dedicated
research institute with strength in cellular, animal and human toxicology,
with an emphasis on neurotoxicology. Co-leadership of this proposal is
located in the nearby OHSU School of Medicine Department of Pediatrics which,
together with participation from the Division of Medical Informatics and the
Department of Medical and Molecular Genetics, brings strength in genomics,
proteomics and bioinformatics, with emphasis on the developing brain and child
health. Core Cl combines these components to support the toxicogenomics
research needs of the TRCP and the Research Projects, PI-P3. Project 1
examines growth factor signaling in neural cells and its modulation by the
neurotoxic anti-cancer drug taxol. Project 2 investigates early and late
effects of genotoxic agents on neural development. Project 3, a subcontract
with MGH, determines if neural and glial cells, as well as cells from
different genetic strains, have overlapping or distinct patterns of toxicant-induced
changes in gene expression that affect specific cellular functions,
such as migration and division. The OHSU-MGH collaboration further
strengthens this application by pooling our respective ongoing toxicogenomics
studies and building an interdependent relationship for the benefit of the
Consortium. Additionally, the participation in this proposal of scientific
leaders of the NIEHS-funded Superfund Basic Research Center (SBRC) at OHSU
(located in CROET) will ensure that the benefits of TRC membership are rapidly
spread to other NIEHS-supported investigators at CROET and its collaborating
SBRC institutions in the Pacific Northwest.
This is an application to become a Member of the NIEHS Toxicogenomics Research
Consortium. The application originates from the synergistic fusion of two
components of the Oregon Health Sciences University (OHSU), the resulting
entity working in close cooperation with the Massachusetts General Hospital
(MGH) at Harvard University. Leadership of this research program and the
Toxicology Research Core Project (TRCP) is located in the OHSU Center for
Research on Occupational and Environmental Toxicology (CROET), a dedicated
research institute with strength in cellular, animal and human toxicology,
with an emphasis on neurotoxicology. Co-leadership of this proposal is
located in the nearby OHSU School of Medicine Department of Pediatrics which,
together with participation from the Division of Medical Informatics and the
Department of Medical and Molecular Genetics, brings strength in genomics,
proteomics and bioinformatics, with emphasis on the developing brain and child
health. Core Cl combines these components to support the toxicogenomics
research needs of the TRCP and the Research Projects, PI-P3. Project 1
examines growth factor signaling in neural cells and its modulation by the
neurotoxic anti-cancer drug taxol. Project 2 investigates early and late
effects of genotoxic agents on neural development. Project 3, a subcontract
with MGH, determines if neural and glial cells, as well as cells from
different genetic strains, have overlapping or distinct patterns of toxicant-induced
changes in gene expression that affect specific cellular functions,
such as migration and division. The OHSU-MGH collaboration further
strengthens this application by pooling our respective ongoing toxicogenomics
studies and building an interdependent relationship for the benefit of the
Consortium. Additionally, the participation in this proposal of scientific
leaders of the NIEHS-funded Superfund Basic Research Center (SBRC) at OHSU
(located in CROET) will ensure that the benefits of TRC membership are rapidly
spread to other NIEHS-supported investigators at CROET and its collaborating
SBRC institutions in the Pacific Northwest.
| Status | Finished |
|---|---|
| Effective start/end date | 9/30/01 → 7/31/08 |
Funding
- National Institutes of Health: $1,985,456.00
- National Institutes of Health: $49,900.00
- National Institutes of Health: $1,112,032.00
- National Institutes of Health: $1,543,368.00
- National Institutes of Health: $769,694.00
- National Institutes of Health: $1,539,388.00
- National Institutes of Health: $1,739,038.00
ASJC
- Environmental Science(all)
- Medicine(all)
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