14th International HLA and Immunogenetics Workshop Prospective Chronic Rejection Project: a three-year follow-up analysis.

M. Ozawa; P. I. Terasaki; R. Castro; J. Alberu; L. Morales-Buenrostro; I. Alvarez; R. Toledo; H. Alvez; M. Monteiro; J. Teixeira; P. Campbell; M. Ciszek; D. Charron; C. Gautreau; F. Christiansen; L. Langan; R. Conca; H. Grosse-Wilde; F. Heinemann; M. Kamoun; T. Kobayashi; P. Kupatawintu; W. LeFor; N. Mehra; A. Panigrahi; D. Norman; A. Piazza; F. Poli; R. Roy; C. Schonemann; N. Lachmann; G. Sireci; K. Tanabe; H. Ishida; E. Van den Berg-Loonen; A. Zeevi

14th International HLA and Immunogenetics Workshop Prospective Chronic Rejection Project: a three-year follow-up analysis.

M. Ozawa, P. I. Terasaki, R. Castro, J. Alberu, L. Morales-Buenrostro, I. Alvarez, R. Toledo, H. Alvez, M. Monteiro, J. Teixeira, P. Campbell, M. Ciszek, D. Charron, C. Gautreau, F. Christiansen, L. Langan, R. Conca, H. Grosse-Wilde, F. Heinemann, M. KamounT. Kobayashi, P. Kupatawintu, W. LeFor, N. Mehra, A. Panigrahi, D. Norman, A. Piazza, F. Poli, R. Roy, C. Schonemann, N. Lachmann, G. Sireci, K. Tanabe, H. Ishida, E. Van den Berg-Loonen, A. Zeevi

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15 Scopus citations

Abstract

The three-year follow-up of 4,144 patients of the 14th International Workshop Prospective Chronic Rejection study has reinforced the evidence that post-transplant HLA antibodies are predictive of long-term graft loss. Three years after a single testing for HLA antibodies, 10% of kidney recipients who were antibody-positive had lost their grafts, in contrast to only 5% of antibody-negative patients (p<0.0001). The adverse effect of post-transplant antibodies on graft survival was also observed in lung, heart, and liver transplants. Donor-specific antibodies and 'strong' non-DSA had stronger association with graft loss than 'moderate' non-DSA. Periodic antibody monitoring, combined with specificity and strength analysis, would help in the early identification of allograft recipients who are at high risk of graft failure.

Original language	English (US)
Pages (from-to)	255-260
Number of pages	6
Journal	Clinical transplants
State	Published - 2007
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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Ozawa, M., Terasaki, P. I., Castro, R., Alberu, J., Morales-Buenrostro, L., Alvarez, I., Toledo, R., Alvez, H., Monteiro, M., Teixeira, J., Campbell, P., Ciszek, M., Charron, D., Gautreau, C., Christiansen, F., Langan, L., Conca, R., Grosse-Wilde, H., Heinemann, F., ... Zeevi, A. (2007). 14th International HLA and Immunogenetics Workshop Prospective Chronic Rejection Project: a three-year follow-up analysis. Clinical transplants, 255-260.

Ozawa, M, Terasaki, PI, Castro, R, Alberu, J, Morales-Buenrostro, L, Alvarez, I, Toledo, R, Alvez, H, Monteiro, M, Teixeira, J, Campbell, P, Ciszek, M, Charron, D, Gautreau, C, Christiansen, F, Langan, L, Conca, R, Grosse-Wilde, H, Heinemann, F, Kamoun, M, Kobayashi, T, Kupatawintu, P, LeFor, W, Mehra, N, Panigrahi, A, Norman, D, Piazza, A, Poli, F, Roy, R, Schonemann, C, Lachmann, N, Sireci, G, Tanabe, K, Ishida, H, Van den Berg-Loonen, E & Zeevi, A 2007, '14th International HLA and Immunogenetics Workshop Prospective Chronic Rejection Project: a three-year follow-up analysis.', Clinical transplants, pp. 255-260.

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title = "14th International HLA and Immunogenetics Workshop Prospective Chronic Rejection Project: a three-year follow-up analysis.",

abstract = "The three-year follow-up of 4,144 patients of the 14th International Workshop Prospective Chronic Rejection study has reinforced the evidence that post-transplant HLA antibodies are predictive of long-term graft loss. Three years after a single testing for HLA antibodies, 10% of kidney recipients who were antibody-positive had lost their grafts, in contrast to only 5% of antibody-negative patients (p<0.0001). The adverse effect of post-transplant antibodies on graft survival was also observed in lung, heart, and liver transplants. Donor-specific antibodies and 'strong' non-DSA had stronger association with graft loss than 'moderate' non-DSA. Periodic antibody monitoring, combined with specificity and strength analysis, would help in the early identification of allograft recipients who are at high risk of graft failure.",

author = "M. Ozawa and Terasaki, {P. I.} and R. Castro and J. Alberu and L. Morales-Buenrostro and I. Alvarez and R. Toledo and H. Alvez and M. Monteiro and J. Teixeira and P. Campbell and M. Ciszek and D. Charron and C. Gautreau and F. Christiansen and L. Langan and R. Conca and H. Grosse-Wilde and F. Heinemann and M. Kamoun and T. Kobayashi and P. Kupatawintu and W. LeFor and N. Mehra and A. Panigrahi and D. Norman and A. Piazza and F. Poli and R. Roy and C. Schonemann and N. Lachmann and G. Sireci and K. Tanabe and H. Ishida and {Van den Berg-Loonen}, E. and A. Zeevi",

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T2 - a three-year follow-up analysis.

AU - Ozawa, M.

AU - Terasaki, P. I.

AU - Castro, R.

AU - Alberu, J.

AU - Morales-Buenrostro, L.

AU - Alvarez, I.

AU - Toledo, R.

AU - Alvez, H.

AU - Monteiro, M.

AU - Teixeira, J.

AU - Campbell, P.

AU - Ciszek, M.

AU - Charron, D.

AU - Gautreau, C.

AU - Christiansen, F.

AU - Langan, L.

AU - Conca, R.

AU - Grosse-Wilde, H.

AU - Heinemann, F.

AU - Kamoun, M.

AU - Kobayashi, T.

AU - Kupatawintu, P.

AU - LeFor, W.

AU - Mehra, N.

AU - Panigrahi, A.

AU - Norman, D.

AU - Piazza, A.

AU - Poli, F.

AU - Roy, R.

AU - Schonemann, C.

AU - Lachmann, N.

AU - Sireci, G.

AU - Tanabe, K.

AU - Ishida, H.

AU - Van den Berg-Loonen, E.

AU - Zeevi, A.

PY - 2007

Y1 - 2007

N2 - The three-year follow-up of 4,144 patients of the 14th International Workshop Prospective Chronic Rejection study has reinforced the evidence that post-transplant HLA antibodies are predictive of long-term graft loss. Three years after a single testing for HLA antibodies, 10% of kidney recipients who were antibody-positive had lost their grafts, in contrast to only 5% of antibody-negative patients (p<0.0001). The adverse effect of post-transplant antibodies on graft survival was also observed in lung, heart, and liver transplants. Donor-specific antibodies and 'strong' non-DSA had stronger association with graft loss than 'moderate' non-DSA. Periodic antibody monitoring, combined with specificity and strength analysis, would help in the early identification of allograft recipients who are at high risk of graft failure.

AB - The three-year follow-up of 4,144 patients of the 14th International Workshop Prospective Chronic Rejection study has reinforced the evidence that post-transplant HLA antibodies are predictive of long-term graft loss. Three years after a single testing for HLA antibodies, 10% of kidney recipients who were antibody-positive had lost their grafts, in contrast to only 5% of antibody-negative patients (p<0.0001). The adverse effect of post-transplant antibodies on graft survival was also observed in lung, heart, and liver transplants. Donor-specific antibodies and 'strong' non-DSA had stronger association with graft loss than 'moderate' non-DSA. Periodic antibody monitoring, combined with specificity and strength analysis, would help in the early identification of allograft recipients who are at high risk of graft failure.

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AN - SCOPUS:49149102696

SN - 0890-9016

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JO - Clinical transplants

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ER -

14th International HLA and Immunogenetics Workshop Prospective Chronic Rejection Project: a three-year follow-up analysis.

Abstract

ASJC Scopus subject areas

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