5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala

S. Sugita; K. Z. Shen; R. A. North

doi:10.1016/0896-6273(92)90121-S

5-hydroxytryptamine is a fast excitatory transmitter at 5-HT₃ receptors in rat amygdala

S. Sugita
, K. Z. Shen
, R. A. North

Neurology

Research output: Contribution to journal › Article › peer-review

170 Scopus citations

Abstract

A fast excitatory synaptic potential mediated by 5-hydroxytryptamine (5-HT) was recorded in rat lateral amygdala neurons in brain slices. The synaptic potential has brief duration (tens of milliseconds), is mimicked by 5-HT, is potentiated by a 5-HT uptake inhibitor, and is blocked by selective 5-HT₃ receptor antagonists. The underlying synaptic current reversed polarity at about 0 mV. This is an example of fast neurotransmission in the mammalian brain mediated by an amine rather than an amino acid. The antiemetic, anxiolytic, and perhaps antipsychotic actions of 5-HT₃ antagonists might result from blockade of such synapses.

Original language	English (US)
Pages (from-to)	199-203
Number of pages	5
Journal	Neuron
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/0896-6273(92)90121-S
State	Published - Jan 1992

Funding

We thank A. Surprenant and J. T. Williams for discussions and Eli LillyCompanyforagiftoffluoxetine.Thisworkwasupported by the National Institutes of Health and by Glaxo Group UK.

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/0896-6273(92)90121-S

Cite this

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title = "5-hydroxytryptamine is a fast excitatory transmitter at 5-HT3 receptors in rat amygdala",

abstract = "A fast excitatory synaptic potential mediated by 5-hydroxytryptamine (5-HT) was recorded in rat lateral amygdala neurons in brain slices. The synaptic potential has brief duration (tens of milliseconds), is mimicked by 5-HT, is potentiated by a 5-HT uptake inhibitor, and is blocked by selective 5-HT3 receptor antagonists. The underlying synaptic current reversed polarity at about 0 mV. This is an example of fast neurotransmission in the mammalian brain mediated by an amine rather than an amino acid. The antiemetic, anxiolytic, and perhaps antipsychotic actions of 5-HT3 antagonists might result from blockade of such synapses.",

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AU - North, R. A.

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N2 - A fast excitatory synaptic potential mediated by 5-hydroxytryptamine (5-HT) was recorded in rat lateral amygdala neurons in brain slices. The synaptic potential has brief duration (tens of milliseconds), is mimicked by 5-HT, is potentiated by a 5-HT uptake inhibitor, and is blocked by selective 5-HT3 receptor antagonists. The underlying synaptic current reversed polarity at about 0 mV. This is an example of fast neurotransmission in the mammalian brain mediated by an amine rather than an amino acid. The antiemetic, anxiolytic, and perhaps antipsychotic actions of 5-HT3 antagonists might result from blockade of such synapses.

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