TY - JOUR
T1 - 50-Gram glucose challenge test
T2 - Is it indicative of outcomes in women without gestational diabetes mellitus?
AU - Yee, Lynn M.
AU - Cheng, Yvonne W.
AU - Liddell, Jennifer
AU - Block-Kurbisch, Ingrid
AU - Caughey, Aaron B.
N1 - Funding Information:
Dr. Caughey is supported by the Robert Wood Johnson Foundation as Physician Faculty Scholar RWJF-61535. Dr. Yvonne W. Cheng is supported by the UCSF Women’s Reproductive Health Research Career Development Award, NIH, the Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12 HD001262).
PY - 2011/9
Y1 - 2011/9
N2 - Objective.To examine whether the 50-gram glucose challenge test (GCT) is associated with perinatal outcomes in women without gestational diabetes mellitus (GDM). Methods.This is a retrospective cohort study of 13,789 women who received the GCT and did not have a diagnosis of GDM at the University of California, San Francisco UCSF. GCT values were categorized and examined as predictors of perinatal morbidity using chi-square test and multivariable logistic regression analyses adjusting for maternal characteristics. Results.In women with an elevated GCT but without GDM, the odds of preeclampsia, cesarean delivery, and elevated birth weight were increased. The odds of large-for-gestational age status were increased with aOR 2.0 (95% CI 1.382.90) in the 160179 mg/dl group. The odds of shoulder dystocia was increased with aOR 3.35 (CI 1.0310.88) in the≥180mg/dl group. Conclusion.In women without GDM, elevated 50-gram GCT values were associated with higher odds of perinatal morbidity. These findings further support evidence that impaired glucose tolerance is a continuum with possible associated adverse outcomes even at mild ranges; additional research is required to investigate appropriate interventions for women with abnormal screens for GDM.
AB - Objective.To examine whether the 50-gram glucose challenge test (GCT) is associated with perinatal outcomes in women without gestational diabetes mellitus (GDM). Methods.This is a retrospective cohort study of 13,789 women who received the GCT and did not have a diagnosis of GDM at the University of California, San Francisco UCSF. GCT values were categorized and examined as predictors of perinatal morbidity using chi-square test and multivariable logistic regression analyses adjusting for maternal characteristics. Results.In women with an elevated GCT but without GDM, the odds of preeclampsia, cesarean delivery, and elevated birth weight were increased. The odds of large-for-gestational age status were increased with aOR 2.0 (95% CI 1.382.90) in the 160179 mg/dl group. The odds of shoulder dystocia was increased with aOR 3.35 (CI 1.0310.88) in the≥180mg/dl group. Conclusion.In women without GDM, elevated 50-gram GCT values were associated with higher odds of perinatal morbidity. These findings further support evidence that impaired glucose tolerance is a continuum with possible associated adverse outcomes even at mild ranges; additional research is required to investigate appropriate interventions for women with abnormal screens for GDM.
KW - Gestational diabetes mellitus
KW - glucose challenge test
KW - perinatal outcomes
KW - screening
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U2 - 10.3109/14767058.2010.546450
DO - 10.3109/14767058.2010.546450
M3 - Article
C2 - 21261449
AN - SCOPUS:80052710426
SN - 1476-7058
VL - 24
SP - 1102
EP - 1106
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
IS - 9
ER -