5.15 - The Brainstem and Nociceptive Modulation

Mary M. Heinricher; Susan L. Ingram

doi:10.1016/B978-0-12-809324-5.24236-3

5.15 - The Brainstem and Nociceptive Modulation

Mary M. Heinricher, Susan L. Ingram

Neurosurgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

The descending pain modulatory circuit through the PAG and RVM modulates pain bidirectionally; increasing or dampening pain in response to internal and environmental stressors. This circuit also mediates the central analgesic actions of opioids. Neuroimaging studies confirm the involvement of the PAG and RVM as important in top-down modulation of pain in humans, including effects of placebo or changes in pain modulation with attention. This chapter includes an overview of the PAG and RVM, neurotransmitter systems that modulate activity of neurons within each area and the properties of pain-modulating neurons in acute and chronic pain.

Original language	English (US)
Title of host publication	The Senses
Subtitle of host publication	A Comprehensive Reference: Volume 1-7, Second Edition
Publisher	Elsevier
Pages	249-271
Number of pages	23
Volume	5
ISBN (Electronic)	9780128054093
ISBN (Print)	9780128054086
DOIs	https://doi.org/10.1016/B978-0-12-809324-5.24236-3
State	Published - Jan 1 2020

Keywords

Analgesia
Antinociception
Cannabinoid
Chronic pain
Descending pain modulatory circuit
Inflammation
Neuropathic pain
Opioid
Pain
Pain-modulation
Periaqueductal gray
Rostral ventromedial medulla

ASJC Scopus subject areas

General Medicine
General Neuroscience

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10.1016/B978-0-12-809324-5.24236-3

Cite this

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title = "5.15 - The Brainstem and Nociceptive Modulation",

abstract = "The descending pain modulatory circuit through the PAG and RVM modulates pain bidirectionally; increasing or dampening pain in response to internal and environmental stressors. This circuit also mediates the central analgesic actions of opioids. Neuroimaging studies confirm the involvement of the PAG and RVM as important in top-down modulation of pain in humans, including effects of placebo or changes in pain modulation with attention. This chapter includes an overview of the PAG and RVM, neurotransmitter systems that modulate activity of neurons within each area and the properties of pain-modulating neurons in acute and chronic pain.",

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AU - Ingram, Susan L.

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KW - Cannabinoid

KW - Chronic pain

KW - Descending pain modulatory circuit

KW - Inflammation

KW - Neuropathic pain

KW - Opioid

KW - Pain

KW - Pain-modulation

KW - Periaqueductal gray

KW - Rostral ventromedial medulla

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BT - The Senses

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ER -

5.15 - The Brainstem and Nociceptive Modulation

Abstract

Keywords

ASJC Scopus subject areas

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