TY - JOUR
T1 - A 16-channel loop array for in vivo macaque whole-brain imaging at 3 T
AU - Quan, Zhiyan
AU - Gao, Yang
AU - Qu, Shuxian
AU - Wang, Xiaojie
AU - Friedman, Robert M.
AU - Chernov, Mykyta M.
AU - Kroenke, Christopher D.
AU - Roe, Anna Wang
AU - Zhang, Xiaotong
N1 - Funding Information:
The authors would like to thank the following people for assisting with this work: Michael Reusz, Zheng Liu, and Jialu Zhang for helpful discussions and technical support. Funding support was provided by the National Key Research and Development Program of China (2018YFA0701400), National Natural Science Foundation of China (81701774, 61771423, 31627802 and 81430010), Zhejiang Lab (2018EB0ZX01), Science and Technology Program of Guangdong (2018B030333001) and Oregon Health & Science University Institutional funds.
Funding Information:
The authors would like to thank the following people for assisting with this work: Michael Reusz, Zheng Liu, and Jialu Zhang for helpful discussions and technical support. Funding support was provided by the National Key Research and Development Program of China ( 2018YFA0701400 ), National Natural Science Foundation of China ( 81701774 , 61771423 , 31627802 and 81430010 ), Zhejiang Lab ( 2018EB0ZX01 ), Science and Technology Program of Guangdong ( 2018B030333001 ) and Oregon Health & Science University Institutional funds.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/5
Y1 - 2020/5
N2 - Non-human primates (NHPs) are vital models for neuroscience research. These animals have been widely used in behavioral, electrophysiological, molecular, and more recently, multimodal neuroimaging and neuro-engineering studies. Several RF coil arrays have been designed for functional, high-resolution brain magnetic resonance imaging (MRI), but few have been designed to accommodate multimodal devices. In the present study, a 16-channel array coil was constructed for brain imaging of macaques at 3 Tesla (3 T). To construct this coil, a close-fitting helmet-shaped form was designed to host 16 coil loops for whole-brain coverage. This assembly is mountable onto stereotaxic head frame bars, and the coil functions while the monkey is in the sphinx position with a clear line of vision of stimuli presented from outside of the MRI system. In addition, 4 openings were allocated in the coil housing, allowing multimodal devices to directly access visual cortical regions such as V1-V4 and MT. Coil performance was evaluated in an anesthetized macaque by quantifying and comparing signal-to-noise ratios (SNRs), noise correlations, and g-factor maps to a vendor-supplied human pediatric coil frequently used for NHP MRI. The result from in vivo experiments showed that the NHP coil was well-decoupled, had higher SNRs in cortical regions, and improved data acquisition acceleration capability compared with a vendor-supplied human pediatric coil that has been frequently used in macaque MRI studies. Furthermore, whole-brain anatomic imaging, diffusion tensor imaging and functional brain imaging have also been conducted: the details of brain anatomical structure, such as cerebellum and brainstem, can be clearly visualized in T2-SPACE images; b0 SNR calculated from b0 maps was higher than the human pediatric coil in all regions of interest (ROIs); the time-course SNR (tSNR) map calculated for GRE-EPI images demonstrates that the presented coil can be used for high-resolution functional imaging at 3 T.
AB - Non-human primates (NHPs) are vital models for neuroscience research. These animals have been widely used in behavioral, electrophysiological, molecular, and more recently, multimodal neuroimaging and neuro-engineering studies. Several RF coil arrays have been designed for functional, high-resolution brain magnetic resonance imaging (MRI), but few have been designed to accommodate multimodal devices. In the present study, a 16-channel array coil was constructed for brain imaging of macaques at 3 Tesla (3 T). To construct this coil, a close-fitting helmet-shaped form was designed to host 16 coil loops for whole-brain coverage. This assembly is mountable onto stereotaxic head frame bars, and the coil functions while the monkey is in the sphinx position with a clear line of vision of stimuli presented from outside of the MRI system. In addition, 4 openings were allocated in the coil housing, allowing multimodal devices to directly access visual cortical regions such as V1-V4 and MT. Coil performance was evaluated in an anesthetized macaque by quantifying and comparing signal-to-noise ratios (SNRs), noise correlations, and g-factor maps to a vendor-supplied human pediatric coil frequently used for NHP MRI. The result from in vivo experiments showed that the NHP coil was well-decoupled, had higher SNRs in cortical regions, and improved data acquisition acceleration capability compared with a vendor-supplied human pediatric coil that has been frequently used in macaque MRI studies. Furthermore, whole-brain anatomic imaging, diffusion tensor imaging and functional brain imaging have also been conducted: the details of brain anatomical structure, such as cerebellum and brainstem, can be clearly visualized in T2-SPACE images; b0 SNR calculated from b0 maps was higher than the human pediatric coil in all regions of interest (ROIs); the time-course SNR (tSNR) map calculated for GRE-EPI images demonstrates that the presented coil can be used for high-resolution functional imaging at 3 T.
KW - 3 T
KW - Multimodal neuroimaging
KW - Non-human primates
KW - RF coil
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U2 - 10.1016/j.mri.2020.02.008
DO - 10.1016/j.mri.2020.02.008
M3 - Article
C2 - 32081631
AN - SCOPUS:85079633149
SN - 0730-725X
VL - 68
SP - 167
EP - 172
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
ER -