A BCR-ABL Mutant Lacking Direct Binding Sites for the GRB2, CBL and CRKL Adapter Proteins Fails to Induce Leukemia in Mice

Agriculture & Biology

• leukemia 52%
• binding sites 42%
• myeloid leukemia 35%
• phosphotransferases (kinases) 31%
• mutants 29%
• mice 28%
• multiprotein complexes 17%
• interleukin-3 17%
• proteins 16%
• mitogen-activated protein kinase 13%
• cells 11%
• phosphorylation 10%
• cell lines 9%
• mutation 8%

Medicine & Life Sciences

• CRKL protein 100%
• Leukemia 40%
• Binding Sites 38%
• Leukemia, Myelogenous, Chronic, BCR-ABL Positive 20%
• Proteins 18%
• Interleukin-3 11%
• Mitogen-Activated Protein Kinase Kinases 10%
• Phosphatidylinositol 3-Kinases 9%
• Protein-Tyrosine Kinases 9%
• Phosphotransferases 7%
• Phosphorylation 6%
• Cell Line 5%
• Mutation 5%
• In Vitro Techniques 4%

Chemical Compounds

• Binding Site 35%
• Chemical Transformation 31%
• Protein 20%
• Tyrosine 9%
• Mutation 8%