TY - JOUR
T1 - A biomechanical analysis of venous tissue in its normal and post-phlebitic conditions
AU - McGilvray, Kirk C.
AU - Sarkar, Rajabrata
AU - Nguyen, Khanh
AU - Puttlitz, Christian M.
N1 - Funding Information:
This work was supported by a grant from the National Institutes of Health ( 01HL083917 ). All authors were fully involved in the study and preparation of the manuscript and the material within has not been and will not be submitted for publication elsewhere.
PY - 2010/11/16
Y1 - 2010/11/16
N2 - Although biomechanical studies of the normal rat vein wall have been reported (Weizsacker, 1988; Plante, 2002), there are no published studies that have investigated the mechanical effects of thrombus formation on murine venous tissue. In response to the lack of knowledge concerning the mechanical consequences of thrombus resolution, distinct thrombus-induced changes in the biomechanical properties of the murine vena cava were measured via biaxial stretch experiments. These data served as input for strain energy function (SEF) fitting and modeling (Gasser et al., 2006). Statistical differences were observed between healthy and diseased tissue with respect to the structural coefficient that represents the response of the non-collagenous, isotropic ground substance. Alterations following thrombus formation were also noted for the SEF coefficient which describes the anisotropic contribution of the fibers. The data indicate ligation of the vena cava leads to structural alterations in the ground substance and collagen fiber network.
AB - Although biomechanical studies of the normal rat vein wall have been reported (Weizsacker, 1988; Plante, 2002), there are no published studies that have investigated the mechanical effects of thrombus formation on murine venous tissue. In response to the lack of knowledge concerning the mechanical consequences of thrombus resolution, distinct thrombus-induced changes in the biomechanical properties of the murine vena cava were measured via biaxial stretch experiments. These data served as input for strain energy function (SEF) fitting and modeling (Gasser et al., 2006). Statistical differences were observed between healthy and diseased tissue with respect to the structural coefficient that represents the response of the non-collagenous, isotropic ground substance. Alterations following thrombus formation were also noted for the SEF coefficient which describes the anisotropic contribution of the fibers. The data indicate ligation of the vena cava leads to structural alterations in the ground substance and collagen fiber network.
KW - Biaxial stretch experiment
KW - Biomechanics
KW - Deep vein thrombosis (DVT)
KW - Post-phlebitic veins
KW - Strain energy function
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U2 - 10.1016/j.jbiomech.2010.07.012
DO - 10.1016/j.jbiomech.2010.07.012
M3 - Article
C2 - 20864110
AN - SCOPUS:78149408955
SN - 0021-9290
VL - 43
SP - 2941
EP - 2947
JO - Journal of Biomechanics
JF - Journal of Biomechanics
IS - 15
ER -