A case-control study of twin pairs discordant for Parkinson’s disease: A search for environmental risk factors

Nadir E. Bharucha; Lynette Stokes; Bruce S. Schoenberg; Christopher Ward; Susan Ince; John G. Nutt; Roswell Eldridge; Donald B. Calne; Nathan Mantel; Roger Duvoisin

doi:10.1212/wnl.36.2.284

A case-control study of twin pairs discordant for Parkinson’s disease: A search for environmental risk factors

Nadir E. Bharucha, Lynette Stokes, Bruce S. Schoenberg, Christopher Ward, Susan Ince, John G. Nutt, Roswell Eldridge, Donald B. Calne, Nathan Mantel, Roger Duvoisin

Neurology

Research output: Contribution to journal › Article › peer-review

90 Scopus citations

Abstract

A previous study of twins with Parkinson’s disease (PD) revealed low concordance, suggesting that genetic factors play a minor role in the etiology of PD. To identify possible environmental determinants of PD while maximally controlling for hereditary factors, 31 monozygotic twin pairs discordant for PD were interviewed by telephone. Information about possible risk factors was obtained from systematic and uniform interviews with cases and controls. The only statistically significant result was less cigarette smoking by PD patients (p < 0.05). Thirteen dizygotic discordant twin pairs were evaluated with the same techniques, but there were no statistically significant differences between affected and unaffected twins.

Original language	English (US)
Pages (from-to)	284-288
Number of pages	5
Journal	Neurology
Volume	36
Issue number	2
DOIs	https://doi.org/10.1212/wnl.36.2.284
State	Published - Feb 1986

ASJC Scopus subject areas

Clinical Neurology

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10.1212/wnl.36.2.284

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title = "A case-control study of twin pairs discordant for Parkinson{\textquoteright}s disease: A search for environmental risk factors",

abstract = "A previous study of twins with Parkinson{\textquoteright}s disease (PD) revealed low concordance, suggesting that genetic factors play a minor role in the etiology of PD. To identify possible environmental determinants of PD while maximally controlling for hereditary factors, 31 monozygotic twin pairs discordant for PD were interviewed by telephone. Information about possible risk factors was obtained from systematic and uniform interviews with cases and controls. The only statistically significant result was less cigarette smoking by PD patients (p < 0.05). Thirteen dizygotic discordant twin pairs were evaluated with the same techniques, but there were no statistically significant differences between affected and unaffected twins.",

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T1 - A case-control study of twin pairs discordant for Parkinson’s disease

T2 - A search for environmental risk factors

AU - Bharucha, Nadir E.

AU - Stokes, Lynette

AU - Schoenberg, Bruce S.

AU - Ward, Christopher

AU - Ince, Susan

AU - Nutt, John G.

AU - Eldridge, Roswell

AU - Calne, Donald B.

AU - Mantel, Nathan

AU - Duvoisin, Roger

PY - 1986/2

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AB - A previous study of twins with Parkinson’s disease (PD) revealed low concordance, suggesting that genetic factors play a minor role in the etiology of PD. To identify possible environmental determinants of PD while maximally controlling for hereditary factors, 31 monozygotic twin pairs discordant for PD were interviewed by telephone. Information about possible risk factors was obtained from systematic and uniform interviews with cases and controls. The only statistically significant result was less cigarette smoking by PD patients (p < 0.05). Thirteen dizygotic discordant twin pairs were evaluated with the same techniques, but there were no statistically significant differences between affected and unaffected twins.

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A case-control study of twin pairs discordant for Parkinson’s disease: A search for environmental risk factors

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