A cobaloxime-mediated synthesis of the ras farnesyl-protein transferase inhibitor chaetomellic acid A

Keyphrases

• Farnesyl 100%
• Myristoyl 100%
• Mediated Synthesis 100%
• Cobaloxime 100%
• Transferases 100%
• Bromide 50%
• Active Form 50%
• Biologically Active 50%
• Anhydride 50%
• Sulfide Oxidation 50%
• Dianion 50%
• Overall Yield 50%
• Basic Hydrolysis 50%
• Diphenyl Disulfide 50%
• Syn-elimination 50%
• Citraconic Anhydride 50%
• High-level Synthesis 50%
• Chemoselective Cross-coupling 50%

Chemistry

• Anhydride 100%
• protein farnesyltransferase inhibitor 100%
• Sulfide 50%
• Disulfide 50%
• Chemoselectivity 50%
• Enzymatic Hydrolysis 50%
• Hydrolysis 50%
• Biphenyl 50%