TY - JOUR
T1 - A comparison of cyclobenzaprine and placebo in the management of fibrositis
AU - Bennett, Robert M.
AU - Gatter, Robert A.
AU - Campbell, Stephen M.
AU - Andrews, Ronald P.
AU - Clark, Sharon R.
AU - Scarola, Joseph A.
PY - 1988/12
Y1 - 1988/12
N2 - The efficacy of cyclobenzaprine (Flexeril), as compared with placebo, was tested in a 12‐week, double‐blind, controlled trial of 120 patients with fibrositis. Of the patients who received placebo, 52% dropped out due to lack of efficacy of the drug, compared with 16% of patients taking cyclobenzaprine. The dropout rate due to adverse reactions was similar in the 2 groups. Patients taking cyclobenzaprine experienced a significant decrease in the severity of pain and a significant increase in the quality of sleep. There was a trend toward improvement in the symptoms of fatigue, but morning stiffness was not alleviated. These improvements in symptoms were associated with a significant reduction in the total number of tender points and in muscle tightness. Our findings indicate that cyclobenzaprine is a useful adjunct in treating patients with the fibrositis syndrome.
AB - The efficacy of cyclobenzaprine (Flexeril), as compared with placebo, was tested in a 12‐week, double‐blind, controlled trial of 120 patients with fibrositis. Of the patients who received placebo, 52% dropped out due to lack of efficacy of the drug, compared with 16% of patients taking cyclobenzaprine. The dropout rate due to adverse reactions was similar in the 2 groups. Patients taking cyclobenzaprine experienced a significant decrease in the severity of pain and a significant increase in the quality of sleep. There was a trend toward improvement in the symptoms of fatigue, but morning stiffness was not alleviated. These improvements in symptoms were associated with a significant reduction in the total number of tender points and in muscle tightness. Our findings indicate that cyclobenzaprine is a useful adjunct in treating patients with the fibrositis syndrome.
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U2 - 10.1002/art.1780311210
DO - 10.1002/art.1780311210
M3 - Article
C2 - 3058130
AN - SCOPUS:0024270558
SN - 0004-3591
VL - 31
SP - 1535
EP - 1542
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
IS - 12
ER -