A conditioned stimulus decreases extracellular dopamine in the nucleus accumbens after the development of a learned taste aversion

G. P. Mark; D. S. Blander; B. G. Hoebel

doi:10.1016/0006-8993(91)90946-S

A conditioned stimulus decreases extracellular dopamine in the nucleus accumbens after the development of a learned taste aversion

G. P. Mark, D. S. Blander, B. G. Hoebel

Research output: Contribution to journal › Article › peer-review

141 Scopus citations

Abstract

The conditioned taste aversion (CTA) paradigm and microdialysis were used to determine if extracellular dopamine in the nucleus accumbens is related to the reward value of a stimulus. Intraorally applied saccharin caused a 37% increase in DA in naive rats and a 40% decrease in subjects with a CTA to this taste. These results suggest that accumbens DA is not just a function of arousal but is related to stimulus reward.

Original language	English (US)
Pages (from-to)	308-310
Number of pages	3
Journal	Brain research
Volume	551
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(91)90946-S
State	Published - Jun 14 1991
Externally published	Yes

Keywords

Conditioned taste aversion
Dopamine
Microdialysis
Nucleus accumbens

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(91)90946-S

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abstract = "The conditioned taste aversion (CTA) paradigm and microdialysis were used to determine if extracellular dopamine in the nucleus accumbens is related to the reward value of a stimulus. Intraorally applied saccharin caused a 37% increase in DA in naive rats and a 40% decrease in subjects with a CTA to this taste. These results suggest that accumbens DA is not just a function of arousal but is related to stimulus reward.",

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AU - Hoebel, B. G.

PY - 1991/6/14

Y1 - 1991/6/14

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AB - The conditioned taste aversion (CTA) paradigm and microdialysis were used to determine if extracellular dopamine in the nucleus accumbens is related to the reward value of a stimulus. Intraorally applied saccharin caused a 37% increase in DA in naive rats and a 40% decrease in subjects with a CTA to this taste. These results suggest that accumbens DA is not just a function of arousal but is related to stimulus reward.

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KW - Dopamine

KW - Microdialysis

KW - Nucleus accumbens

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A conditioned stimulus decreases extracellular dopamine in the nucleus accumbens after the development of a learned taste aversion

Abstract

Keywords

ASJC Scopus subject areas

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