A delayed injection-site reaction in a patient receiving extended-release naltrexone

Keith Ahamad, P. Todd Korthuis, Paula J. Lum, Cheyenne Johnson, Evan Wood

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Background: Pharmacotherapy, such as oral naltrexone, has proven effective in treating alcohol use disorder, although medication adherence has presented challenges. Although a formulation of extended-release naltrexone for intramuscular injection has been developed to counter daily adherence issues, injection-site reactions can occur within days of depot injection. Case: The authors report a case of an individual with alcohol use disorder who had a previously undescribed delayed injection-site reaction that occurred 11 days after injection. Subsequent challenge with the medication resulted in recurrence of the reaction. Discussion: Although extended-release naltrexone is generally well tolerated, injection-site reactions can complicate treatment and can appear more than 10 days after medication administration.

Original languageEnglish (US)
Pages (from-to)278-280
Number of pages3
JournalSubstance Abuse
Issue number2
StatePublished - Apr 2 2016


  • Alcohol use disorder
  • extended-release naltrexone
  • injection-site reaction

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health


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