A delayed injection-site reaction in a patient receiving extended-release naltrexone

Keith Ahamad; P. Todd Korthuis; Paula J. Lum; Cheyenne Johnson; Evan Wood

doi:10.1080/08897077.2016.1138919

A delayed injection-site reaction in a patient receiving extended-release naltrexone

Keith Ahamad, P. Todd Korthuis, Paula J. Lum, Cheyenne Johnson, Evan Wood

Department of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Pharmacotherapy, such as oral naltrexone, has proven effective in treating alcohol use disorder, although medication adherence has presented challenges. Although a formulation of extended-release naltrexone for intramuscular injection has been developed to counter daily adherence issues, injection-site reactions can occur within days of depot injection. Case: The authors report a case of an individual with alcohol use disorder who had a previously undescribed delayed injection-site reaction that occurred 11 days after injection. Subsequent challenge with the medication resulted in recurrence of the reaction. Discussion: Although extended-release naltrexone is generally well tolerated, injection-site reactions can complicate treatment and can appear more than 10 days after medication administration.

Original language	English (US)
Pages (from-to)	278-280
Number of pages	3
Journal	Substance Abuse
Volume	37
Issue number	2
DOIs	https://doi.org/10.1080/08897077.2016.1138919
State	Published - Apr 2 2016

Keywords

Alcohol use disorder
extended-release naltrexone
injection-site reaction

ASJC Scopus subject areas

Medicine (miscellaneous)
Psychiatry and Mental health

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10.1080/08897077.2016.1138919

Cite this

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title = "A delayed injection-site reaction in a patient receiving extended-release naltrexone",

abstract = "Background: Pharmacotherapy, such as oral naltrexone, has proven effective in treating alcohol use disorder, although medication adherence has presented challenges. Although a formulation of extended-release naltrexone for intramuscular injection has been developed to counter daily adherence issues, injection-site reactions can occur within days of depot injection. Case: The authors report a case of an individual with alcohol use disorder who had a previously undescribed delayed injection-site reaction that occurred 11 days after injection. Subsequent challenge with the medication resulted in recurrence of the reaction. Discussion: Although extended-release naltrexone is generally well tolerated, injection-site reactions can complicate treatment and can appear more than 10 days after medication administration.",

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A delayed injection-site reaction in a patient receiving extended-release naltrexone

Abstract

Keywords

ASJC Scopus subject areas

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