Abstract
Getting the right exposure. Membrane-tethered epidermal growth factor (EGF) is found to modulate substrate attachment and spreading of human breast epithelial cells by EGF-EGFR signaling interactions. In a newly implemented system, the fluidity of the supported membrane enables localized enrichment of ligand density in a configuration that reflects cognate-receptor distribution on the cell surface. This technique provides a means to control soluble ligand exposure within a parallel-surface array format.
Original language | English (US) |
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Pages (from-to) | 436-440 |
Number of pages | 5 |
Journal | ChemBioChem |
Volume | 7 |
Issue number | 3 |
DOIs | |
State | Published - Mar 2006 |
Externally published | Yes |
Keywords
- Cell assay
- Growth factors
- Membranes
- Receptor tyrosine kinase
- Soluble signaling ligand
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Organic Chemistry