A Histone Deacetylase Regulates Addiction

Soren Impey

Research output: Contribution to journalShort surveypeer-review

12 Scopus citations


Epigenetic modification of chromatin has been proposed to translate environmental stimuli into persistent "cellular memories." Recent studies suggest that epigenetic pathways regulate long-term behavioral adaptation in the nervous system. In this issue of Neuron, Renthal et al. utilize genetic manipulations of HDAC5 to provide strong evidence for a role for histone acetylation in the behavioral response to cocaine.

Original languageEnglish (US)
Pages (from-to)415-417
Number of pages3
Issue number3
StatePublished - Nov 8 2007

ASJC Scopus subject areas

  • General Neuroscience


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