A microsatellite-based index map of human chromosome 11

M. Litt; P. Kramer; X. Y. Hauge; J. L. Weber; Z. Wang; P. J. Wilkle; M. S. Holt; S. Mishra; H. Donis-keller; L. Warnich; A. E. Retief; C. Jones; J. Welssenbach

doi:10.1093/hmg/2.7.909

A microsatellite-based index map of human chromosome 11

M. Litt, P. Kramer, X. Y. Hauge, J. L. Weber, Z. Wang, P. J. Wilkle, M. S. Holt, S. Mishra, H. Donis-keller, L. Warnich, A. E. Retief, C. Jones, J. Welssenbach

Neurology

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

We have constructed a continuous Index map of 25 micosatellite markers on human chromosome 11. The markers have been typed in 40 CEPH families, have heterozygositles of 69% or higher and can be typed by PCR. The odds against inversion of adjacent marker loci order are at least 10⁵: 1. The sex average map covers a total of 162 cM with no gap exceeding 15 cM. Total lengths for female and male maps are 205 and 123 cM, respectively. By use of a hybrid cell panel or by in situ hybridization, 16 of the markers have also been mapped cytogenetically, providing a good correlation of the Index map with the cytogenetic map. The map will facilltate high resolution mapping of additional polymorphic loci and of disease genes on chromosome 11.

Original language	English (US)
Pages (from-to)	909-913
Number of pages	5
Journal	Human molecular genetics
Volume	2
Issue number	7
DOIs	https://doi.org/10.1093/hmg/2.7.909
State	Published - Jul 1993

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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10.1093/hmg/2.7.909

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@article{2692a38729f04088ab16b3073db19fc8,

title = "A microsatellite-based index map of human chromosome 11",

abstract = "We have constructed a continuous Index map of 25 micosatellite markers on human chromosome 11. The markers have been typed in 40 CEPH families, have heterozygositles of 69% or higher and can be typed by PCR. The odds against inversion of adjacent marker loci order are at least 105: 1. The sex average map covers a total of 162 cM with no gap exceeding 15 cM. Total lengths for female and male maps are 205 and 123 cM, respectively. By use of a hybrid cell panel or by in situ hybridization, 16 of the markers have also been mapped cytogenetically, providing a good correlation of the Index map with the cytogenetic map. The map will facilltate high resolution mapping of additional polymorphic loci and of disease genes on chromosome 11.",

author = "M. Litt and P. Kramer and Hauge, {X. Y.} and Weber, {J. L.} and Z. Wang and Wilkle, {P. J.} and Holt, {M. S.} and S. Mishra and H. Donis-keller and L. Warnich and Retief, {A. E.} and C. Jones and J. Welssenbach",

note = "Funding Information: This work was supported by NTH Grant #HGO0022. We thank the CEPH for providing DNA samples from reference families. Rum litt, Trias Phromchotikul, and Eric Smith provided excellent technical assistance.",

year = "1993",

month = jul,

doi = "10.1093/hmg/2.7.909",

language = "English (US)",

volume = "2",

pages = "909--913",

journal = "Human molecular genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "7",

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T1 - A microsatellite-based index map of human chromosome 11

AU - Litt, M.

AU - Kramer, P.

AU - Hauge, X. Y.

AU - Weber, J. L.

AU - Wang, Z.

AU - Wilkle, P. J.

AU - Holt, M. S.

AU - Mishra, S.

AU - Donis-keller, H.

AU - Warnich, L.

AU - Retief, A. E.

AU - Jones, C.

AU - Welssenbach, J.

N1 - Funding Information: This work was supported by NTH Grant #HGO0022. We thank the CEPH for providing DNA samples from reference families. Rum litt, Trias Phromchotikul, and Eric Smith provided excellent technical assistance.

PY - 1993/7

Y1 - 1993/7

N2 - We have constructed a continuous Index map of 25 micosatellite markers on human chromosome 11. The markers have been typed in 40 CEPH families, have heterozygositles of 69% or higher and can be typed by PCR. The odds against inversion of adjacent marker loci order are at least 105: 1. The sex average map covers a total of 162 cM with no gap exceeding 15 cM. Total lengths for female and male maps are 205 and 123 cM, respectively. By use of a hybrid cell panel or by in situ hybridization, 16 of the markers have also been mapped cytogenetically, providing a good correlation of the Index map with the cytogenetic map. The map will facilltate high resolution mapping of additional polymorphic loci and of disease genes on chromosome 11.

AB - We have constructed a continuous Index map of 25 micosatellite markers on human chromosome 11. The markers have been typed in 40 CEPH families, have heterozygositles of 69% or higher and can be typed by PCR. The odds against inversion of adjacent marker loci order are at least 105: 1. The sex average map covers a total of 162 cM with no gap exceeding 15 cM. Total lengths for female and male maps are 205 and 123 cM, respectively. By use of a hybrid cell panel or by in situ hybridization, 16 of the markers have also been mapped cytogenetically, providing a good correlation of the Index map with the cytogenetic map. The map will facilltate high resolution mapping of additional polymorphic loci and of disease genes on chromosome 11.

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SP - 909

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JO - Human molecular genetics

JF - Human molecular genetics

IS - 7

ER -

A microsatellite-based index map of human chromosome 11

Abstract

ASJC Scopus subject areas

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