A new class of reversible cell cycle inhibitors

Benjamin D. Hoffman, Hartmut M. Hanauske‐Abel, Alan Flint, Marc Lalande

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


The effects of three compounds on the cell cycle of HL‐60 promyeloid leukemia cells has been examined. Ciclopirox olamine, an antifungal agent, and the compound Hoechst 768159 reversibly block the cell cycle at a point occurring roughly 1 h before the arrest mediated by aphidicolin, an inhibitor of DNA polymerase á activity, which acts in early S phase. Similar results are also obtained with the compound mimosine, a plant amino acid. Based on these data, it is concluded that all three agents inhibit cell cycle traverse at or very near the G1/S phase boundary and identify a previously undefined reversible cell cycle arrest point.

Original languageEnglish (US)
Pages (from-to)26-32
Number of pages7
Issue number1
StatePublished - 1991
Externally publishedYes


  • Flow cytometry
  • G1 phase block
  • ciclopirox olamine
  • mimosine

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Biophysics
  • Hematology
  • Endocrinology
  • Cell Biology


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