A new cone-shaped aortic valve prosthesis for orthotopic position: An experimental study in swine

Jan Šochman, Jan H. Peregrin, Zdeněk Pulda, Dusan Pavcnik, Barry T. Uchida, Hans A. Timmermans, Josef Rösch

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The aim of this experimental study was to evaluate a newly designed cone-shaped aortic valve prosthesis (CAVP) for one-step transcatheter placement in an orthotopic position. The study was conducted in 15 swine using either the transcarotid (11 animals) or the transfemoral (4 animals) artery approach. A 12- or 13-Fr sheath was inserted via arterial cutdown. The CAVP was deployed under fluoroscopic control and its struts, by design, induced significant native valve insufficiency. CAVP function was evaluated by aortography and aortic pressure curve tracing. In 11 of 15 swine the CAVP was properly deployed and functioned well throughout the scheduled period of 2-3 h. In three swine the CAVPs were placed lower than intended, however, they were functional even in the left ventricular outflow tract position. One swine expired due to inadvertent low CAVP placement that caused both aortic regurgitation and immobilization of the anterior mitral valve leaflet by the valve struts. We conclude that this design of CAVP is relatively easy to deploy, works well throughout a short time period (2-3 h), and, moreover, seems to be reliable even in a lower-than-orthotopic position (e.g., infra-annulary space). Longer-term studies are needed for its further evaluation.

Original languageEnglish (US)
Pages (from-to)330-335
Number of pages6
JournalCardiovascular and interventional radiology
Issue number2
StatePublished - Apr 2010
Externally publishedYes


  • Aortic regurgitation
  • Catheterization techniques
  • Cone valve prosthesis
  • Experimental research

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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