A position effect on the time of replication origin activation in yeast

Betsy M. Ferguson, Walton L. Fangman

Research output: Contribution to journalArticlepeer-review

222 Scopus citations


The chromosomes of eukaryotes are characterized by the mosaic nature of their replication - large regions of DNA that replicate early in S phase are interspersed with regions that replicate late. This pattern of early and late synthesis appears to be the consequence of a temporal program that activates replication origins at different times. The basis of this temporal regulation in the yeast S. cerevisiae has been investigated by changing the chromosomal locations of two origins, one activated early in the S phase (ARS1) and one activated late (ARS501). We show that the cis-acting information controlling time of activation can be separated from the element that determines origin function. For the ARS501 origin, late activation appears to be a consequence of its proximity to the telomere.

Original languageEnglish (US)
Pages (from-to)333-339
Number of pages7
Issue number2
StatePublished - Jan 24 1992
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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