Abstract
Introduction: There is an unmet need for effective methods for conducting dementia prevention trials. Methods: Home-based assessment study compared feasibility and efficiency, ability to capture change over time using in-home instruments, and ability to predict cognitive conversion using predefined triggers in a randomized clinical trial in (1)mail-in questionnaire/live telephone interviews, (2)automated telephone/interactive voice recognition, and (3)internet-based computer Kiosk technologies. Primary endpoint was defined as cognitive conversion. Results: Analysis followed a modified intent-to-treat principle. Dropout rates were low and similar across technologies but participants in Kiosk were more likely to dropout earlier. Staff resources needed were higher in Kiosk. In-home instruments distinguished conversion and stable groups. Cognitively stable group showed improvement in cognitive measures. Triggering was associated with higher likelihood of conversion but statistically significant only in mail-in questionnaire/live telephone interviews. Discussion: Relatively low efficiency of internet-based assessment compared with testing by live-assessors has implications for internet-based recruitment and assessment efforts currently proposed for diverse populations.
Original language | English (US) |
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Pages (from-to) | 615-624 |
Number of pages | 10 |
Journal | Alzheimer's and Dementia |
Volume | 15 |
Issue number | 5 |
DOIs | |
State | Published - May 2019 |
Keywords
- Alzheimer's disease
- Dementia prevention
- Home-based assessment
- Randomized clinical trial
ASJC Scopus subject areas
- Clinical Neurology
- Geriatrics and Gerontology
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience
- Health Policy
- Developmental Neuroscience
- Epidemiology