A report of Epstein-Barr virus-positive primary cutaneous natural killer-/T-cell lymphoma

Sareeta R.S. Parker, Alvin R. Solomon, Joshua E. Lane

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5 Scopus citations


We describe a patient who presented with Epstein-Barr virus-positive tumor-stage primary cutaneous lymphoma. Our patient had previously been treated with oral methotrexate for long-standing rheumatoid arthritis. Tissue analysis revealed large tumor cells that were surface CD2- and CD3-positive; T-cell-restricted intracellular antigen-positive; CD56-, CD20-, and CD30-negative; and stained positively for Epstein-Barr virus. Our case is noteworthy for several reasons. Although the presence of rheumatoid arthritis and therapy with methotrexate are putative risk factors for the development of immune suppression-related and Epstein-Barr virus-related lymphomas, the vast majority of lymphomas in this setting are of B-cell origin, and rarely are these primary cutaneous in nature. In addition, our patient's tumor displayed an unusual phenotype, with immunophenotypic features suggestive of an atypical natural killer-/T-cell lymphoma. Methotrexate was withdrawn, and our patient was successfully treated with local radiotherapy. She has remained in complete remission 28 months since diagnosis.

Original languageEnglish (US)
Pages (from-to)157-161
Number of pages5
JournalJournal of the American Academy of Dermatology
Issue number1
StatePublished - Jul 2008
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology


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