TY - JOUR
T1 - A roadmap to a columnar visual cortical prosthetic
AU - Roe, Anna Wang
AU - Chen, Gang
AU - Xu, Augix Guohua
AU - Hu, Jiaming
N1 - Funding Information:
This work was supported by: the National Key R&D Program of China2018YFA0701400 (to A.W.R.), the National Natural Science Foundation of China (81430010 and 31627802, to A.W.R.; U1909205 and 31471052 to G.C.), the key research and development program of Zhejiang province2020C03004 (to A.W.R.), the National Hi-Tech Research and Development Program Grant 2015AA020515 (to A.W.R.), the Zhejiang Provincial Natural Science Foundation Grant 31471052 (to G.C.), and the Fundamental Research Funds for the Central Universities Grant 2015WN81007 (to G.C.). No funds from OHSU or NIH were used in the preparation of this manuscript.
Funding Information:
This work was supported by: the National Key R&D Program of China 2018YFA0701400 (to A.W.R.), the National Natural Science Foundation of China ( 81430010 and 31627802 , to A.W.R.; U1909205 and 31471052 to G.C.), the key research and development program of Zhejiang province 2020C03004 (to A.W.R.), the National Hi-Tech Research and Development Program Grant 2015AA020515 (to A.W.R.), the Zhejiang Provincial Natural Science Foundation Grant 31471052 (to G.C.), and the Fundamental Research Funds for the Central Universities Grant 2015WN81007 (to G.C.). No funds from OHSU or NIH were used in the preparation of this manuscript.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/8
Y1 - 2020/8
N2 - Visual blindness affects many millions globally and severely impacts quality of life. One approach to overcome visual blindness is the direct electrical microstimulation of brain circuits normally engaged in visual function. Attempts to do so with traditional brain-machine interfaces (BMI) in monkeys and humans have evoked percepts (phosphenes) described as crude featureless spots of light. Here, we propose to qualitatively enhance these percepts by recruiting submillimeter units of cortical representation (cortical columns) which encode rich visual features such as color, motion, shape, and faces. A three step roadmap is proposed, comprising: (1) the mapping of column-based networks (columnar connectomes), (2) connectome-guided studies of circuitry and perception, and (3) column-targeted design of optical BMIs. We predict this approach will increase the specificity and sophistication needed for realistic, vibrant visual perception.
AB - Visual blindness affects many millions globally and severely impacts quality of life. One approach to overcome visual blindness is the direct electrical microstimulation of brain circuits normally engaged in visual function. Attempts to do so with traditional brain-machine interfaces (BMI) in monkeys and humans have evoked percepts (phosphenes) described as crude featureless spots of light. Here, we propose to qualitatively enhance these percepts by recruiting submillimeter units of cortical representation (cortical columns) which encode rich visual features such as color, motion, shape, and faces. A three step roadmap is proposed, comprising: (1) the mapping of column-based networks (columnar connectomes), (2) connectome-guided studies of circuitry and perception, and (3) column-targeted design of optical BMIs. We predict this approach will increase the specificity and sophistication needed for realistic, vibrant visual perception.
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U2 - 10.1016/j.cophys.2020.06.009
DO - 10.1016/j.cophys.2020.06.009
M3 - Review article
AN - SCOPUS:85088374275
SN - 2468-8681
VL - 16
SP - 68
EP - 78
JO - Current Opinion in Physiology
JF - Current Opinion in Physiology
ER -