Abstract
Four putative hairpin structures (hairpins A to D) are involved in the specific encapsidation of Moloney murine leukemia virus (M-MuLV) RNA into M- MuLV virus particles. The C and D elements, encompassing M-MuLV viral nucleotides 310 to 374, facilitate encapsidation of heterologous RNA into virions. Thus, these two elements appear to act as a core RNA encapsidation signal. The loop sequences of the putative C and D hairpins are identical (GACG). However, when GACG loops were introduced into RNAs on heterologous stem sequences, they increased encapsidation levels only three- to fourfold. These results suggest that C and D stem-and-loop sequences contribute to the M-MuLV cis-acting site for encapsidation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8061-8065 |
| Number of pages | 5 |
| Journal | Journal of virology |
| Volume | 71 |
| Issue number | 10 |
| DOIs | |
| State | Published - 1997 |
ASJC Scopus subject areas
- Microbiology
- Immunology
- Insect Science
- Virology