A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents

Chelsea Carpenter; John Sidney; Ravi Kolla; Kaustuv Nayak; Helena Tomiyama; Claudia Tomiyama; Oscar A. Padilla; Virginie Rozot; Syed F. Ahamed; Carlos Ponte; Valeria Rolla; Paulo R. Antas; Anmol Chandele; John Kenneth; Seetha Laxmi; Edward Makgotlho; Valentina Vanini; Giuseppe Ippolito; Alexandra S. Kazanova; Alexander V. Panteleev; Willem Hanekom; Harriet Mayanja-Kizza; David Lewinsohn; Mayuko Saito; M. Juliana McElrath; W. Henry Boom; Delia Goletti; Robert Gilman; Irina V. Lyadova; Thomas J. Scriba; Esper G. Kallas; Kaja Murali-Krishna; Alessandro Sette; Cecilia S. Lindestam Arlehamn

doi:10.1016/j.tube.2015.07.001

A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents

Chelsea Carpenter, John Sidney, Ravi Kolla, Kaustuv Nayak, Helena Tomiyama, Claudia Tomiyama, Oscar A. Padilla, Virginie Rozot, Syed F. Ahamed, Carlos Ponte, Valeria Rolla, Paulo R. Antas, Anmol Chandele, John Kenneth, Seetha Laxmi, Edward Makgotlho, Valentina Vanini, Giuseppe Ippolito, Alexandra S. Kazanova, Alexander V. PanteleevWillem Hanekom, Harriet Mayanja-Kizza, David Lewinsohn, Mayuko Saito, M. Juliana McElrath, W. Henry Boom, Delia Goletti, Robert Gilman, Irina V. Lyadova, Thomas J. Scriba, Esper G. Kallas, Kaja Murali-Krishna, Alessandro Sette, Cecilia S. Lindestam Arlehamn

Pulmonary and Critical Care Medicine

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis (MTB) antigens in individuals latently infected with MTB (LTBI), and uninfected individuals with previous BCG vaccination, from nine locations and populations with different HLA distribution, MTB exposure rates, and standards of TB care. This comparison revealed similar response magnitudes in diverse LTBI and BCG-vaccinated cohorts and significant correlation between responses in LTBIs from the USA and other locations. Many antigens were uniformly recognized, suggesting suitability for inclusion in vaccines targeting diverse populations. Several antigens were similarly immunodominant in LTBI and BCG cohorts, suggesting applicability for vaccines aimed at boosting BCG responses. The panel of MTB antigens will be valuable for characterizing MTB-specific CD4 T cell responses irrespective of ethnicity, infecting MTB strains and BCG vaccination status. Our results illustrate how a comparative analysis can provide insight into the relative immunogenicity of existing and novel vaccine candidates in LTBIs.

Original language	English (US)
Pages (from-to)	713-721
Number of pages	9
Journal	Tuberculosis
Volume	95
Issue number	6
DOIs	https://doi.org/10.1016/j.tube.2015.07.001
State	Published - Dec 1 2015

Keywords

BCG
CD4
LTBI
T cell antigen
Tuberculosis
Vaccine

ASJC Scopus subject areas

Microbiology
Immunology
Microbiology (medical)
Infectious Diseases

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10.1016/j.tube.2015.07.001

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Carpenter, C., Sidney, J., Kolla, R., Nayak, K., Tomiyama, H., Tomiyama, C., Padilla, O. A., Rozot, V., Ahamed, S. F., Ponte, C., Rolla, V., Antas, P. R., Chandele, A., Kenneth, J., Laxmi, S., Makgotlho, E., Vanini, V., Ippolito, G., Kazanova, A. S., ... Lindestam Arlehamn, C. S. (2015). A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents. Tuberculosis, 95(6), 713-721. https://doi.org/10.1016/j.tube.2015.07.001

Carpenter, C, Sidney, J, Kolla, R, Nayak, K, Tomiyama, H, Tomiyama, C, Padilla, OA, Rozot, V, Ahamed, SF, Ponte, C, Rolla, V, Antas, PR, Chandele, A, Kenneth, J, Laxmi, S, Makgotlho, E, Vanini, V, Ippolito, G, Kazanova, AS, Panteleev, AV, Hanekom, W, Mayanja-Kizza, H, Lewinsohn, D, Saito, M, McElrath, MJ, Boom, WH, Goletti, D, Gilman, R, Lyadova, IV, Scriba, TJ, Kallas, EG, Murali-Krishna, K, Sette, A & Lindestam Arlehamn, CS 2015, 'A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents', Tuberculosis, vol. 95, no. 6, pp. 713-721. https://doi.org/10.1016/j.tube.2015.07.001

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title = "A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents",

abstract = "We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis (MTB) antigens in individuals latently infected with MTB (LTBI), and uninfected individuals with previous BCG vaccination, from nine locations and populations with different HLA distribution, MTB exposure rates, and standards of TB care. This comparison revealed similar response magnitudes in diverse LTBI and BCG-vaccinated cohorts and significant correlation between responses in LTBIs from the USA and other locations. Many antigens were uniformly recognized, suggesting suitability for inclusion in vaccines targeting diverse populations. Several antigens were similarly immunodominant in LTBI and BCG cohorts, suggesting applicability for vaccines aimed at boosting BCG responses. The panel of MTB antigens will be valuable for characterizing MTB-specific CD4 T cell responses irrespective of ethnicity, infecting MTB strains and BCG vaccination status. Our results illustrate how a comparative analysis can provide insight into the relative immunogenicity of existing and novel vaccine candidates in LTBIs.",

keywords = "BCG, CD4, LTBI, T cell antigen, Tuberculosis, Vaccine",

author = "Chelsea Carpenter and John Sidney and Ravi Kolla and Kaustuv Nayak and Helena Tomiyama and Claudia Tomiyama and Padilla, {Oscar A.} and Virginie Rozot and Ahamed, {Syed F.} and Carlos Ponte and Valeria Rolla and Antas, {Paulo R.} and Anmol Chandele and John Kenneth and Seetha Laxmi and Edward Makgotlho and Valentina Vanini and Giuseppe Ippolito and Kazanova, {Alexandra S.} and Panteleev, {Alexander V.} and Willem Hanekom and Harriet Mayanja-Kizza and David Lewinsohn and Mayuko Saito and McElrath, {M. Juliana} and Boom, {W. Henry} and Delia Goletti and Robert Gilman and Lyadova, {Irina V.} and Scriba, {Thomas J.} and Kallas, {Esper G.} and Kaja Murali-Krishna and Alessandro Sette and {Lindestam Arlehamn}, {Cecilia S.}",

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AU - Carpenter, Chelsea

AU - Sidney, John

AU - Kolla, Ravi

AU - Nayak, Kaustuv

AU - Tomiyama, Helena

AU - Tomiyama, Claudia

AU - Padilla, Oscar A.

AU - Rozot, Virginie

AU - Ahamed, Syed F.

AU - Ponte, Carlos

AU - Rolla, Valeria

AU - Antas, Paulo R.

AU - Chandele, Anmol

AU - Kenneth, John

AU - Laxmi, Seetha

AU - Makgotlho, Edward

AU - Vanini, Valentina

AU - Ippolito, Giuseppe

AU - Kazanova, Alexandra S.

AU - Panteleev, Alexander V.

AU - Hanekom, Willem

AU - Mayanja-Kizza, Harriet

AU - Lewinsohn, David

AU - Saito, Mayuko

AU - McElrath, M. Juliana

AU - Boom, W. Henry

AU - Goletti, Delia

AU - Gilman, Robert

AU - Lyadova, Irina V.

AU - Scriba, Thomas J.

AU - Kallas, Esper G.

AU - Murali-Krishna, Kaja

AU - Sette, Alessandro

AU - Lindestam Arlehamn, Cecilia S.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis (MTB) antigens in individuals latently infected with MTB (LTBI), and uninfected individuals with previous BCG vaccination, from nine locations and populations with different HLA distribution, MTB exposure rates, and standards of TB care. This comparison revealed similar response magnitudes in diverse LTBI and BCG-vaccinated cohorts and significant correlation between responses in LTBIs from the USA and other locations. Many antigens were uniformly recognized, suggesting suitability for inclusion in vaccines targeting diverse populations. Several antigens were similarly immunodominant in LTBI and BCG cohorts, suggesting applicability for vaccines aimed at boosting BCG responses. The panel of MTB antigens will be valuable for characterizing MTB-specific CD4 T cell responses irrespective of ethnicity, infecting MTB strains and BCG vaccination status. Our results illustrate how a comparative analysis can provide insight into the relative immunogenicity of existing and novel vaccine candidates in LTBIs.

AB - We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis (MTB) antigens in individuals latently infected with MTB (LTBI), and uninfected individuals with previous BCG vaccination, from nine locations and populations with different HLA distribution, MTB exposure rates, and standards of TB care. This comparison revealed similar response magnitudes in diverse LTBI and BCG-vaccinated cohorts and significant correlation between responses in LTBIs from the USA and other locations. Many antigens were uniformly recognized, suggesting suitability for inclusion in vaccines targeting diverse populations. Several antigens were similarly immunodominant in LTBI and BCG cohorts, suggesting applicability for vaccines aimed at boosting BCG responses. The panel of MTB antigens will be valuable for characterizing MTB-specific CD4 T cell responses irrespective of ethnicity, infecting MTB strains and BCG vaccination status. Our results illustrate how a comparative analysis can provide insight into the relative immunogenicity of existing and novel vaccine candidates in LTBIs.

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JO - Tuberculosis

JF - Tuberculosis

IS - 6

ER -

A side-by-side comparison of T cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents

Abstract

Keywords

ASJC Scopus subject areas

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