A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction

Juan José Toledo-Aral; Paul Brehm; Simon Halegoua; Gail Mandel

doi:10.1016/0896-6273(95)90317-8

A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction

Juan José Toledo-Aral
, Paul Brehm
, Simon Halegoua
, Gail Mandel

Research output: Contribution to journal › Article › peer-review

151 Scopus citations

Abstract

The continuous presence of nerve growth factor (NGF) is thought to be required for the elaboration of neuronal-like traits in PC12 cells. Surprisingly, we find that a 1 min exposure to NGF is sufficient to engage a longer-term genetic program leading to the acquisition of membrane excitability. Whereas continuous exposure to NGF causes the induction of a family of sodium channels, the effect of a brief exposure is to induce selectively expression of the peripheral nerve-type sodium channel gene PN1, through a distinct signaling pathway requiring immediate-early genes. A 1 min exposure of PC12 cells to interferon-γ also causes PN1 gene induction, suggesting that the "triggered" NGF and interferon-γ signaling pathways share common molecular intermediates.

Original language	English (US)
Pages (from-to)	607-611
Number of pages	5
Journal	Neuron
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/0896-6273(95)90317-8
State	Published - Mar 1995
Externally published	Yes

Funding

The authors acknowledge gratefully Dr. G. D'Arcangelo for sharing her unpublished data and Mr. Zhi-Jun He for help with Northern blot analysis. The work in this report was funded by grants from the NIH (to G. M., P. B., and S. H.) and by a grant from Trophix Pharmaceuticals, Inc. (to S. H.). J. J. T. A. is a postdoctoral fellow of the Spanish Ministerio de Educaci6n y Ciencia.

Funders
Trophix Pharmaceuticals, Inc.
Author National Institutes of Health National Institutes of Health National Institutes of Health National Institutes of Health The Bev Hartig Huntington's Disease Foundation National Institutes of Health

ASJC Scopus subject areas

General Neuroscience

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10.1016/0896-6273(95)90317-8

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title = "A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction",

abstract = "The continuous presence of nerve growth factor (NGF) is thought to be required for the elaboration of neuronal-like traits in PC12 cells. Surprisingly, we find that a 1 min exposure to NGF is sufficient to engage a longer-term genetic program leading to the acquisition of membrane excitability. Whereas continuous exposure to NGF causes the induction of a family of sodium channels, the effect of a brief exposure is to induce selectively expression of the peripheral nerve-type sodium channel gene PN1, through a distinct signaling pathway requiring immediate-early genes. A 1 min exposure of PC12 cells to interferon-γ also causes PN1 gene induction, suggesting that the {"}triggered{"} NGF and interferon-γ signaling pathways share common molecular intermediates.",

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AU - Halegoua, Simon

AU - Mandel, Gail

N1 - Funding Information: The authors acknowledge gratefully Dr. G. D'Arcangelo for sharing her unpublished data and Mr. Zhi-Jun He for help with Northern blot analysis. The work in this report was funded by grants from the NIH (to G. M., P. B., and S. H.) and by a grant from Trophix Pharmaceuticals, Inc. (to S. H.). J. J. T. A. is a postdoctoral fellow of the Spanish Ministerio de Educaci6n y Ciencia.

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N2 - The continuous presence of nerve growth factor (NGF) is thought to be required for the elaboration of neuronal-like traits in PC12 cells. Surprisingly, we find that a 1 min exposure to NGF is sufficient to engage a longer-term genetic program leading to the acquisition of membrane excitability. Whereas continuous exposure to NGF causes the induction of a family of sodium channels, the effect of a brief exposure is to induce selectively expression of the peripheral nerve-type sodium channel gene PN1, through a distinct signaling pathway requiring immediate-early genes. A 1 min exposure of PC12 cells to interferon-γ also causes PN1 gene induction, suggesting that the "triggered" NGF and interferon-γ signaling pathways share common molecular intermediates.

AB - The continuous presence of nerve growth factor (NGF) is thought to be required for the elaboration of neuronal-like traits in PC12 cells. Surprisingly, we find that a 1 min exposure to NGF is sufficient to engage a longer-term genetic program leading to the acquisition of membrane excitability. Whereas continuous exposure to NGF causes the induction of a family of sodium channels, the effect of a brief exposure is to induce selectively expression of the peripheral nerve-type sodium channel gene PN1, through a distinct signaling pathway requiring immediate-early genes. A 1 min exposure of PC12 cells to interferon-γ also causes PN1 gene induction, suggesting that the "triggered" NGF and interferon-γ signaling pathways share common molecular intermediates.

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A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction

Abstract

Funding

ASJC Scopus subject areas

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