@article{4f1c7643b3c64fddaee07043ba25f4c9,
title = "A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development",
abstract = "Lawrenson et al. profile gene expression and active chromatin in ∼200 ovarian and fallopian epithelial isolates and implement machine learning to demonstrate that most high-grade serous ovarian cancers (HGSOCs) derive from fallopian tube epithelial cells, but a subset may originate from ovarian epithelia. SOX18 induces mesenchymal features to drive early neoplasia in fallopian tube precursors.",
keywords = "RNA-seq, SOX18, dual origins, fallopian tube secretory epithelial cell, high-grade serous ovarian cancer, machine learning, one-class logistic regression models, ovarian surface epithelial cell, single-cell RNA-seq, super enhancers, transcription factors",
author = "Kate Lawrenson and Fonseca, {Marcos A.S.} and Liu, {Annie Y.} and {Segato Dezem}, Felipe and Lee, {Janet M.} and Xianzhi Lin and Corona, {Rosario I.} and Forough Abbasi and Vavra, {Kevin C.} and Dinh, {Huy Q.} and Gill, {Navjot Kaur} and Seo, {Ji Heui} and Simon Coetzee and Lin, {Yvonne G.} and Tanja Pejovic and Paulette Mhawech-Fauceglia and Rowat, {Amy C.} and Ronny Drapkin and Karlan, {Beth Y.} and Hazelett, {Dennis J.} and Freedman, {Matthew L.} and Gayther, {Simon A.} and Houtan Noushmehr",
note = "Funding Information: The results shown here are, in part, based upon data generated by the TCGA Research Network: https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga. Some of the normal tissue specimens were collected as part of the USC Jean Richardson Gynecologic Tissue and Fluid Repository, which is supported by a grant from the USC Department of Obstetrics & Gynecology and the NCT Cancer Center Shared Grant award P30 CA014089 (to the Norris Comprehensive Cancer Center). K.L. is supported, in part, by a K99/R00 Pathway to Independence Award from the NIH (R00CA184415), institutional support from the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center, and a Career Development Award from The Tower Cancer Research Foundation. M.A.S.F. is supported by grant 2017/08211-1 from Sao Paulo Research Foundation (FAPESP). H.N. is also supported by an institutional grant (Henry Ford Hospital). N.K.G. is supported by Farber Family Funds. This work was supported, in part, by the Ovarian Cancer Research Fund Alliance Program Project Development Grant (373356): Co-Evolution of Epithelial Ovarian Cancer and Tumor Stroma. Additional support for this work came from NIH/NCI grants 1R01CA211707 and 1R01CA207456 and OCRF award 258807, as well as the Department of Defense Ovarian Cancer Research Program Pilot Award (A.C.R. K.L. and B.Y.K.). Study Concept, Design, and Manuscript Preparation, K.L. S.A.G. and H.N.; Data Generation, K.L. A.Y.L. J.M.L. X.L. A.F. N.K.G. and J.-H.S.; Data Analysis, M.A.S.F. F.S. and H.Q.D.; Sample/Cell Line Provision, Y.G.L. R.D. and B.Y.K.; Pathology Review, P.M.-F.; Technical/Analytic Expertise, K.C.V. S.C. A.C.R. D.J.H. and M.L.F. All authors contributed to the final draft of the manuscript. The authors declare no competing interests. Funding Information: The results shown here are, in part, based upon data generated by the TCGA Research Network: https://www.cancer.gov/about-nci/organization/ccg/research/structural-genomics/tcga . Some of the normal tissue specimens were collected as part of the USC Jean Richardson Gynecologic Tissue and Fluid Repository, which is supported by a grant from the USC Department of Obstetrics & Gynecology and the NCT Cancer Center Shared Grant award P30 CA014089 (to the Norris Comprehensive Cancer Center). K.L. is supported, in part, by a K99/R00 Pathway to Independence Award from the NIH ( R00CA184415 ), institutional support from the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center , and a Career Development Award from The Tower Cancer Research Foundation . M.A.S.F. is supported by grant 2017/08211-1 from Sao Paulo Research Foundation (FAPESP). H.N. is also supported by an institutional grant ( Henry Ford Hospital) . N.K.G. is supported by Farber Family Funds . This work was supported, in part, by the Ovarian Cancer Research Fund Alliance Program Project Development Grant ( 373356 ): Co-Evolution of Epithelial Ovarian Cancer and Tumor Stroma. Additional support for this work came from NIH/NCI grants 1R01CA211707 and 1R01CA207456 and OCRF award 258807 , as well as the Department of Defense Ovarian Cancer Research Program Pilot Award (A.C.R., K.L., and B.Y.K.). Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = dec,
day = "10",
doi = "10.1016/j.celrep.2019.10.122",
language = "English (US)",
volume = "29",
pages = "3726--3735.e4",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "11",
}