A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development

Kate Lawrenson; Marcos A.S. Fonseca; Annie Y. Liu; Felipe Segato Dezem; Janet M. Lee; Xianzhi Lin; Rosario I. Corona; Forough Abbasi; Kevin C. Vavra; Huy Q. Dinh; Navjot Kaur Gill; Ji Heui Seo; Simon Coetzee; Yvonne G. Lin; Tanja Pejovic; Paulette Mhawech-Fauceglia; Amy C. Rowat; Ronny Drapkin; Beth Y. Karlan; Dennis J. Hazelett; Matthew L. Freedman; Simon A. Gayther; Houtan Noushmehr

doi:10.1016/j.celrep.2019.10.122

A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development

Kate Lawrenson, Marcos A.S. Fonseca, Annie Y. Liu, Felipe Segato Dezem, Janet M. Lee, Xianzhi Lin, Rosario I. Corona, Forough Abbasi, Kevin C. Vavra, Huy Q. Dinh, Navjot Kaur Gill, Ji Heui Seo, Simon Coetzee, Yvonne G. Lin, Tanja Pejovic, Paulette Mhawech-Fauceglia, Amy C. Rowat, Ronny Drapkin, Beth Y. Karlan, Dennis J. HazelettMatthew L. Freedman, Simon A. Gayther, Houtan Noushmehr

Obstetrics and Gynecology

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Lawrenson et al. profile gene expression and active chromatin in ∼200 ovarian and fallopian epithelial isolates and implement machine learning to demonstrate that most high-grade serous ovarian cancers (HGSOCs) derive from fallopian tube epithelial cells, but a subset may originate from ovarian epithelia. SOX18 induces mesenchymal features to drive early neoplasia in fallopian tube precursors.

Original language	English (US)
Pages (from-to)	3726-3735.e4
Journal	Cell Reports
Volume	29
Issue number	11
DOIs	https://doi.org/10.1016/j.celrep.2019.10.122
State	Published - Dec 10 2019

Keywords

RNA-seq
SOX18
dual origins
fallopian tube secretory epithelial cell
high-grade serous ovarian cancer
machine learning
one-class logistic regression models
ovarian surface epithelial cell
single-cell RNA-seq
super enhancers
transcription factors

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2019.10.122

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Lawrenson, K., Fonseca, M. A. S., Liu, A. Y., Segato Dezem, F., Lee, J. M., Lin, X., Corona, R. I., Abbasi, F., Vavra, K. C., Dinh, H. Q., Gill, N. K., Seo, J. H., Coetzee, S., Lin, Y. G., Pejovic, T., Mhawech-Fauceglia, P., Rowat, A. C., Drapkin, R., Karlan, B. Y., ... Noushmehr, H. (2019). A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development. Cell Reports, 29(11), 3726-3735.e4. https://doi.org/10.1016/j.celrep.2019.10.122

Lawrenson, K, Fonseca, MAS, Liu, AY, Segato Dezem, F, Lee, JM, Lin, X, Corona, RI, Abbasi, F, Vavra, KC, Dinh, HQ, Gill, NK, Seo, JH, Coetzee, S, Lin, YG, Pejovic, T, Mhawech-Fauceglia, P, Rowat, AC, Drapkin, R, Karlan, BY, Hazelett, DJ, Freedman, ML, Gayther, SA & Noushmehr, H 2019, 'A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development', Cell Reports, vol. 29, no. 11, pp. 3726-3735.e4. https://doi.org/10.1016/j.celrep.2019.10.122

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abstract = "Lawrenson et al. profile gene expression and active chromatin in ∼200 ovarian and fallopian epithelial isolates and implement machine learning to demonstrate that most high-grade serous ovarian cancers (HGSOCs) derive from fallopian tube epithelial cells, but a subset may originate from ovarian epithelia. SOX18 induces mesenchymal features to drive early neoplasia in fallopian tube precursors.",

keywords = "RNA-seq, SOX18, dual origins, fallopian tube secretory epithelial cell, high-grade serous ovarian cancer, machine learning, one-class logistic regression models, ovarian surface epithelial cell, single-cell RNA-seq, super enhancers, transcription factors",

author = "Kate Lawrenson and Fonseca, {Marcos A.S.} and Liu, {Annie Y.} and {Segato Dezem}, Felipe and Lee, {Janet M.} and Xianzhi Lin and Corona, {Rosario I.} and Forough Abbasi and Vavra, {Kevin C.} and Dinh, {Huy Q.} and Gill, {Navjot Kaur} and Seo, {Ji Heui} and Simon Coetzee and Lin, {Yvonne G.} and Tanja Pejovic and Paulette Mhawech-Fauceglia and Rowat, {Amy C.} and Ronny Drapkin and Karlan, {Beth Y.} and Hazelett, {Dennis J.} and Freedman, {Matthew L.} and Gayther, {Simon A.} and Houtan Noushmehr",

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AU - Liu, Annie Y.

AU - Segato Dezem, Felipe

AU - Lee, Janet M.

AU - Lin, Xianzhi

AU - Corona, Rosario I.

AU - Abbasi, Forough

AU - Vavra, Kevin C.

AU - Dinh, Huy Q.

AU - Gill, Navjot Kaur

AU - Seo, Ji Heui

AU - Coetzee, Simon

AU - Lin, Yvonne G.

AU - Pejovic, Tanja

AU - Mhawech-Fauceglia, Paulette

AU - Rowat, Amy C.

AU - Drapkin, Ronny

AU - Karlan, Beth Y.

AU - Hazelett, Dennis J.

AU - Freedman, Matthew L.

AU - Gayther, Simon A.

AU - Noushmehr, Houtan

PY - 2019/12/10

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AB - Lawrenson et al. profile gene expression and active chromatin in ∼200 ovarian and fallopian epithelial isolates and implement machine learning to demonstrate that most high-grade serous ovarian cancers (HGSOCs) derive from fallopian tube epithelial cells, but a subset may originate from ovarian epithelia. SOX18 induces mesenchymal features to drive early neoplasia in fallopian tube precursors.

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KW - fallopian tube secretory epithelial cell

KW - high-grade serous ovarian cancer

KW - machine learning

KW - one-class logistic regression models

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KW - single-cell RNA-seq

KW - super enhancers

KW - transcription factors

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A Study of High-Grade Serous Ovarian Cancer Origins Implicates the SOX18 Transcription Factor in Tumor Development

Abstract

Keywords

ASJC Scopus subject areas

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