A study of respiratory illnesses in infants and nitrogen dioxide exposure

Jonathan M. Samet, William E. Lambert, Betty J. Skipper, Alice H. Cushing, Lee C. McLaren, Margo Schwab, John D. Spengler

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Toxicologic and epidemiologic studies have elevated concern that exposure to nitrogen dioxide (NO2) in outdoor and indoor air may increase the frequency and severity of respiratory infections. We have developed and implemented a prospective cohort study to test the hypothesis that exposure to NO2 increases the incidence and severity of respiratory infections during the first 18 mo of life. This study, which was based on extensive pilot research, was designed to address the potential limitltions of misclassification, confounding, and inadequate power. Enrollment of 1 315 subjects has been completed. This paper reviews the methods used in the study, characteristics of the enrolled subjects, NO2 concentrations in the homes of study participants, and rates of illness occurrence.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalArchives of Environmental Health
Issue number1
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Environmental Chemistry
  • General Environmental Science
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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