A therapy for liver failure found in the JNK yard

Holger Willenbring; Markus Grompe

doi:10.1016/j.cell.2013.03.033

A therapy for liver failure found in the JNK yard

Holger Willenbring, Markus Grompe

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

In the liver, the hepatocyte mass is kept stable through a tight balance between hepatocyte death and proliferation that is frequently lost upon acute or chronic liver injury. Wuestefeld et al. (2013) now identify a potentially druggable target that enhances hepatocyte proliferation and promotes liver regeneration, thereby preventing liver failure.

Original language	English (US)
Pages (from-to)	283-284
Number of pages	2
Journal	Cell
Volume	153
Issue number	2
DOIs	https://doi.org/10.1016/j.cell.2013.03.033
State	Published - Apr 11 2013

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2013.03.033

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title = "A therapy for liver failure found in the JNK yard",

abstract = "In the liver, the hepatocyte mass is kept stable through a tight balance between hepatocyte death and proliferation that is frequently lost upon acute or chronic liver injury. Wuestefeld et al. (2013) now identify a potentially druggable target that enhances hepatocyte proliferation and promotes liver regeneration, thereby preventing liver failure.",

author = "Holger Willenbring and Markus Grompe",

note = "Funding Information: H.W. is supported by CIRM grant RN2-00950 and NIH grant P30 DK26743. M.G. is supported by NIH grant R01 DK05192.",

year = "2013",

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T1 - A therapy for liver failure found in the JNK yard

AU - Willenbring, Holger

AU - Grompe, Markus

N1 - Funding Information: H.W. is supported by CIRM grant RN2-00950 and NIH grant P30 DK26743. M.G. is supported by NIH grant R01 DK05192.

PY - 2013/4/11

Y1 - 2013/4/11

N2 - In the liver, the hepatocyte mass is kept stable through a tight balance between hepatocyte death and proliferation that is frequently lost upon acute or chronic liver injury. Wuestefeld et al. (2013) now identify a potentially druggable target that enhances hepatocyte proliferation and promotes liver regeneration, thereby preventing liver failure.

AB - In the liver, the hepatocyte mass is kept stable through a tight balance between hepatocyte death and proliferation that is frequently lost upon acute or chronic liver injury. Wuestefeld et al. (2013) now identify a potentially druggable target that enhances hepatocyte proliferation and promotes liver regeneration, thereby preventing liver failure.

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A therapy for liver failure found in the JNK yard

Abstract

ASJC Scopus subject areas

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