Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

Pietro De Togni; Joseph Goellner; Nancy H. Ruddle; Philip R. Streeter; Andrea Fick; Sanjeev Mariathasan; Stacy C. Smith; Rebecca Carlson; Laurie P. Shornick; Jena Strauss-Schoenberger; John H. Russell; Robert Karr; David D. Chaplin

doi:10.1126/science.8171322

Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

Pietro De Togni, Joseph Goellner, Nancy H. Ruddle, Philip R. Streeter, Andrea Fick, Sanjeev Mariathasan, Stacy C. Smith, Rebecca Carlson, Laurie P. Shornick, Jena Strauss-Schoenberger, John H. Russell, Robert Karr, David D. Chaplin

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Abstract

Mice rendered deficient in lymphotoxin (LT) by gene targeting in embryonic stem cells have no morphologically detectable lymph nodes or Peyer's patches, although development of the thymus appears normal. Within the white pulp of the spleen, there is failure of normal segregation of B and T cells. Spleen and peripheral blood contain CD4⁺CD8^- and CD4^-CD8⁺ T cells in a normal ratio, and both T cell subsets have an apparently normal lytic function. Lymphocytes positive for immunoglobulin M are present in increased numbers in both the spleen and peripheral blood. These data suggest an essential role for LT in the normal development of peripheral lymphoid organs.

Original language	English (US)
Pages (from-to)	703-707
Number of pages	5
Journal	Science
Volume	264
Issue number	5159
DOIs	https://doi.org/10.1126/science.8171322
State	Published - Apr 29 1994
Externally published	Yes

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title = "Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin",

abstract = "Mice rendered deficient in lymphotoxin (LT) by gene targeting in embryonic stem cells have no morphologically detectable lymph nodes or Peyer's patches, although development of the thymus appears normal. Within the white pulp of the spleen, there is failure of normal segregation of B and T cells. Spleen and peripheral blood contain CD4+CD8- and CD4-CD8+ T cells in a normal ratio, and both T cell subsets have an apparently normal lytic function. Lymphocytes positive for immunoglobulin M are present in increased numbers in both the spleen and peripheral blood. These data suggest an essential role for LT in the normal development of peripheral lymphoid organs.",

author = "{De Togni}, Pietro and Joseph Goellner and Ruddle, {Nancy H.} and Streeter, {Philip R.} and Andrea Fick and Sanjeev Mariathasan and Smith, {Stacy C.} and Rebecca Carlson and Shornick, {Laurie P.} and Jena Strauss-Schoenberger and Russell, {John H.} and Robert Karr and Chaplin, {David D.}",

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doi = "10.1126/science.8171322",

language = "English (US)",

volume = "264",

pages = "703--707",

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TY - JOUR

T1 - Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

AU - De Togni, Pietro

AU - Goellner, Joseph

AU - Ruddle, Nancy H.

AU - Streeter, Philip R.

AU - Fick, Andrea

AU - Mariathasan, Sanjeev

AU - Smith, Stacy C.

AU - Carlson, Rebecca

AU - Shornick, Laurie P.

AU - Strauss-Schoenberger, Jena

AU - Russell, John H.

AU - Karr, Robert

AU - Chaplin, David D.

PY - 1994/4/29

Y1 - 1994/4/29

N2 - Mice rendered deficient in lymphotoxin (LT) by gene targeting in embryonic stem cells have no morphologically detectable lymph nodes or Peyer's patches, although development of the thymus appears normal. Within the white pulp of the spleen, there is failure of normal segregation of B and T cells. Spleen and peripheral blood contain CD4+CD8- and CD4-CD8+ T cells in a normal ratio, and both T cell subsets have an apparently normal lytic function. Lymphocytes positive for immunoglobulin M are present in increased numbers in both the spleen and peripheral blood. These data suggest an essential role for LT in the normal development of peripheral lymphoid organs.

AB - Mice rendered deficient in lymphotoxin (LT) by gene targeting in embryonic stem cells have no morphologically detectable lymph nodes or Peyer's patches, although development of the thymus appears normal. Within the white pulp of the spleen, there is failure of normal segregation of B and T cells. Spleen and peripheral blood contain CD4+CD8- and CD4-CD8+ T cells in a normal ratio, and both T cell subsets have an apparently normal lytic function. Lymphocytes positive for immunoglobulin M are present in increased numbers in both the spleen and peripheral blood. These data suggest an essential role for LT in the normal development of peripheral lymphoid organs.

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Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

Abstract

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