TY - JOUR
T1 - Abnormalities in parentally rated executive function in methamphetamine/polysubstance exposed children
AU - Piper, Brian J.
AU - Acevedo, Summer F.
AU - Kolchugina, Galena K.
AU - Butler, Robert W.
AU - Corbett, Selena M.
AU - Honeycutt, Elizabeth B.
AU - Craytor, Michael J.
AU - Raber, Jacob
N1 - Funding Information:
This research was supported by the National Institute of Drug Abuse ( L30 DA027582-01 , T32 DA07262 and 1P50DA018165 ), the National Institute of Environmental Health Sciences ( T32 ES007060 ), a Public Health Service Grant ( 1 UL1 RR024120-01 & UL1 RR024140 ), the Ellison Medical Foundation ( AG-NS-0201 ), and the Clinical Research Enhancement Fund ( 90120298 ). Anthony Bader, Hilary Gray, Paige Cooper and Collin Clifford provided technical assistance. Finally, we acknowledge Bob Ritchie of the Ponce School of Medicine/RCMI Publications Office (Grant # 5G12RR003050-25 ) for his help with the manuscript preparation.
PY - 2011/5
Y1 - 2011/5
N2 - Methamphetamine/polysubstance abuse in women of childbearing age is a major concern because of the potential long-term detrimental effects on the brain function of the fetus following in utero exposure. A battery of established tests, including the Wechsler Abbreviated Scale of Intelligence, Conners' Continuous Performance Test II, Behavioral Rating Inventory of Executive Function, the CMS Family Pictures and Dot Location tests, the Spatial Span test from the WISC-IV-Integrated, and a recently developed spatial learning and memory measure (Memory Island), was used to assess the effects of prenatal drug exposure on neurobehavioral performance. Participants were 7 to 9 year old children from similar socioeconomic backgrounds who either had (N = 31) or had not (N = 35) been exposed to methamphetamine/polysubstance during pregnancy. Compared to unexposed children, exposed children showed pronounced elevations (i.e. more problems) in parental ratings of executive function, including behavioral regulation and metacognition. Exposed children also exhibited subtle reductions in spatial performance in the Memory Island test. In contrast, IQ, Spatial Span, Family Pictures, Dot Location, and vigilance performance were unaffected by prenatal drug exposure history. Thus, children of women who reported using methamphetamine and other recreational drugs during pregnancy showed a selective profile of abnormalities in parentally rated executive function.
AB - Methamphetamine/polysubstance abuse in women of childbearing age is a major concern because of the potential long-term detrimental effects on the brain function of the fetus following in utero exposure. A battery of established tests, including the Wechsler Abbreviated Scale of Intelligence, Conners' Continuous Performance Test II, Behavioral Rating Inventory of Executive Function, the CMS Family Pictures and Dot Location tests, the Spatial Span test from the WISC-IV-Integrated, and a recently developed spatial learning and memory measure (Memory Island), was used to assess the effects of prenatal drug exposure on neurobehavioral performance. Participants were 7 to 9 year old children from similar socioeconomic backgrounds who either had (N = 31) or had not (N = 35) been exposed to methamphetamine/polysubstance during pregnancy. Compared to unexposed children, exposed children showed pronounced elevations (i.e. more problems) in parental ratings of executive function, including behavioral regulation and metacognition. Exposed children also exhibited subtle reductions in spatial performance in the Memory Island test. In contrast, IQ, Spatial Span, Family Pictures, Dot Location, and vigilance performance were unaffected by prenatal drug exposure history. Thus, children of women who reported using methamphetamine and other recreational drugs during pregnancy showed a selective profile of abnormalities in parentally rated executive function.
KW - Alcohol
KW - Learning
KW - Neuropsychology
KW - Nicotine
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U2 - 10.1016/j.pbb.2011.02.013
DO - 10.1016/j.pbb.2011.02.013
M3 - Article
C2 - 21334365
AN - SCOPUS:79952470941
SN - 0091-3057
VL - 98
SP - 432
EP - 439
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 3
ER -