TY - JOUR
T1 - Absence of Detectable IgM Antibody during Cytomegalovirus Disease in Patients with AIDS
AU - Dylewski, Joseph
AU - Chou, Sunwen
AU - Merigan, Thomas C.
PY - 1983/8/25
Y1 - 1983/8/25
N2 - To the Editor: A great deal of emphasis has been placed on the cell-mediated immune deficits seen in patients with the acquired immunodeficiency syndrome (AIDS).1 2 3 Reports of normal or elevated levels of circulating immunoglobulins have suggested that the humoral system is intact.2,3 Indeed, high levels of IgG-class antibody to cytomegalovirus, Epstein–Barr virus, and hepatitis B are commonly seen in homosexual men with AIDS. Luft et al.4 have described 10 patients with pathologically documented Central-nervous-system toxoplasmosis, with demonstrable IgG but no IgM antibodies to toxoplasma. According to the Centers for Disease Control criteria, these patients would be classified as having AIDS.
AB - To the Editor: A great deal of emphasis has been placed on the cell-mediated immune deficits seen in patients with the acquired immunodeficiency syndrome (AIDS).1 2 3 Reports of normal or elevated levels of circulating immunoglobulins have suggested that the humoral system is intact.2,3 Indeed, high levels of IgG-class antibody to cytomegalovirus, Epstein–Barr virus, and hepatitis B are commonly seen in homosexual men with AIDS. Luft et al.4 have described 10 patients with pathologically documented Central-nervous-system toxoplasmosis, with demonstrable IgG but no IgM antibodies to toxoplasma. According to the Centers for Disease Control criteria, these patients would be classified as having AIDS.
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U2 - 10.1056/NEJM198308253090812
DO - 10.1056/NEJM198308253090812
M3 - Letter
C2 - 6308449
AN - SCOPUS:0020965988
SN - 0028-4793
VL - 309
SP - 493
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 8
ER -