TY - JOUR
T1 - Absence of type I estrogen receptors in choroidal melanoma
T2 - Analysis of Collaborative Ocular Melanoma Study (COMS) eyes
AU - Grostern, Richard J.
AU - Shternfeld, Ilona Slusker
AU - Bacus, Sarah S.
AU - Gilchrist, Kennedy
AU - Zimbric, Michele L.
AU - Albert, Daniel M.
N1 - Funding Information:
This article was supported in part by Grant UIO E406284 from the National Institutes of Health, Bethesda, Maryland, and by a grant from Research to Prevent Blindness, New York.
PY - 2001
Y1 - 2001
N2 - • PURPOSE: To evaluate choroidal melanomas in enucleated eyes for the presence of type I estrogen receptors. • METHODS: Fourteen consecutive eyes with large choroidal melanomas (defined as >16-mm basal diameter and >8 mm thickness) from 14 patients (eight women and six men with a mean age of 57 years; range, 25-74 years) enucleated in accordance with the Collaborative Ocular Melanoma Study (COMS) protocol were investigated. Immunohistochemical techniques were employed to label the choroidal melanomas for the presence of type I estrogen receptors. Each specimen was then evaluated in a masked fashion by an experienced ophthalmic pathologist for positive nuclear staining. •RESULTS: No tumors showed immunohistochemical evidence of a type I estrogen receptor. • CONCLUSION: Type I estrogen receptors are not present in choroidal melanoma. Estrogens are not likely to influence choroidal melanoma growth through traditional receptors.
AB - • PURPOSE: To evaluate choroidal melanomas in enucleated eyes for the presence of type I estrogen receptors. • METHODS: Fourteen consecutive eyes with large choroidal melanomas (defined as >16-mm basal diameter and >8 mm thickness) from 14 patients (eight women and six men with a mean age of 57 years; range, 25-74 years) enucleated in accordance with the Collaborative Ocular Melanoma Study (COMS) protocol were investigated. Immunohistochemical techniques were employed to label the choroidal melanomas for the presence of type I estrogen receptors. Each specimen was then evaluated in a masked fashion by an experienced ophthalmic pathologist for positive nuclear staining. •RESULTS: No tumors showed immunohistochemical evidence of a type I estrogen receptor. • CONCLUSION: Type I estrogen receptors are not present in choroidal melanoma. Estrogens are not likely to influence choroidal melanoma growth through traditional receptors.
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U2 - 10.1016/S0002-9394(00)00959-4
DO - 10.1016/S0002-9394(00)00959-4
M3 - Article
C2 - 11384577
AN - SCOPUS:0035003779
SN - 0002-9394
VL - 131
SP - 788
EP - 791
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 6
ER -