TY - JOUR
T1 - Acceleration of allograft failure by cytomegalovirus
AU - Streblow, Daniel N.
AU - Orloff, Susan L.
AU - Nelson, Jay
N1 - Funding Information:
SL Orloff was supported by a grant from the Department of Veterans Affairs and from the National Institutes of Health (HL 66238-01); NIH grants were also awarded to DN Streblow (HL083194) and JA Nelson (AI21640, HL65754, and HL71695). DN Streblow is also supported by an AHA Scientist Development Grant.
PY - 2007/10
Y1 - 2007/10
N2 - A number of human herpesviruses are important opportunistic pathogens that have been associated with increased morbidity and mortality in transplant recipients including human cytomegalovirus (HCMV), HHV6, HHV7, HHV8 as well as HSV-1, VZV. However, HCMV has been linked both epidemiologically and through the use of animal models to the acceleration of acute and chronic allograft rejection. This review will cover the pathophysiology, epidemiology, and mechanisms of CMV-associated disease in the setting of transplantation.
AB - A number of human herpesviruses are important opportunistic pathogens that have been associated with increased morbidity and mortality in transplant recipients including human cytomegalovirus (HCMV), HHV6, HHV7, HHV8 as well as HSV-1, VZV. However, HCMV has been linked both epidemiologically and through the use of animal models to the acceleration of acute and chronic allograft rejection. This review will cover the pathophysiology, epidemiology, and mechanisms of CMV-associated disease in the setting of transplantation.
UR - http://www.scopus.com/inward/record.url?scp=34648831381&partnerID=8YFLogxK
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U2 - 10.1016/j.coi.2007.07.012
DO - 10.1016/j.coi.2007.07.012
M3 - Review article
C2 - 17716883
AN - SCOPUS:34648831381
SN - 0952-7915
VL - 19
SP - 577
EP - 582
JO - Current opinion in immunology
JF - Current opinion in immunology
IS - 5
ER -