@article{98ccef312d864739907db7db0876dc24,
title = "Accuracy of intrachromosomal gene conversion in mouse cells",
abstract = "Results of several recent studies suggest that homologous recombination and related processes in mammalian cells are highly mutagenic. We have examined the products of intrachromosomal gene conversion events that encompassed the last intron of the chicken thymidine kinase gene.Following plasmid rescue and DNA sequencing, we find no mutations associated with twenty conversion events representing 5380 total base pairs of which 2414 base pairs are intron sequence. Based on these studies we conclude that intrachromosomal gene conversion in mouse cells is not a highly mutagenic process but rather it operates with fidelity.",
author = "Stachelek, {Janet L.} and Liskay, {R. Michael}",
note = "Funding Information: ACKNOWLEDGEMENTS The authors would like to thank Dr. Jesse Kwoh for supplying us with plasmids and for useful discussions on plasmid constructions. We would also like to thank Dr. Kirk Thomas for supplying the bacterial strain HH-1 and for his valuable advice on plasmid rescue procedures, and Dr. Michael Seidman for his advice on the preparation of DNA for sequencing. We would also like to thank Dr. Alan Waldman, Roni Bollag and Alan Godwin for their critical reading of the manuscript. This work was supported by a Public Health Service Grant R01 GM32741 to RML. RHL is a recipient of a Leukemia Society of America Scholar Award.",
year = "1988",
month = may,
day = "11",
doi = "10.1093/nar/16.9.4069",
language = "English (US)",
volume = "16",
pages = "4069--4076",
journal = "Nucleic acids research",
issn = "0305-1048",
publisher = "Oxford University Press",
number = "9",
}