TY - JOUR
T1 - Accuracy of Knowledge-Based Reconstruction for Measurement of Right Ventricular Volume and Function in Patients With Tetralogy of Fallot
AU - Sheehan, Florence H.
AU - Kilner, Philip J.
AU - Sahn, David J.
AU - Vick, G. Wesley
AU - Stout, Karen K.
AU - Ge, Shuping
AU - Helbing, Willem A.
AU - Lewin, Mark
AU - Shurman, Alan J.
AU - Buechel, Emanuela Valsangiacomo
AU - Litt, Harold I.
AU - Waiss, Mary Pierre
N1 - Funding Information:
This study was supported by a grant from VentriPoint, Inc. , Seattle, Washington. Dr. Philip Kilner's participation was funded in part by the British Heart Foundation.
PY - 2010/4/1
Y1 - 2010/4/1
N2 - We tested the accuracy and reproducibility of knowledge-based reconstruction (KBR) for measuring right ventricular (RV) volume and function. KBR enables rapid assessment of the right ventricle from sparse user input by referencing a database. KBR generates a 3-dimensional surface to fit points that the user enters at anatomic landmarks. We measured the RV volume using KBR from magnetic resonance images in 20 patients with repaired tetralogy of Fallot at end-diastole and end-systole. We entered points in the long- and short-axis and/or oblique views. The true volume was computed by manually tracing the RV borders for 3-dimensional reconstruction using the piecewise smooth subdivision surface method. The reference database included 54 patients with tetralogy of Fallot patients. The KBR values agreed closely with the true values for the end-diastolic volume (r = 0.993), end-systolic volume (r = 0.992), and ejection fraction (EF; r = 0.930). KBR slightly overestimated the end-diastolic volume (4 ± 10 ml, p = NS), end-systolic volume (1 ± 9 ml, p = NS), and EF (4 ± 3%, p = NS). No bias in the error was found by Bland-Altman analysis (p = NS for end-diastolic and end-systolic volume and EF). The KBR volumes had approached the true volumes (235 ± 93 vs 243 ± 93, p = 0.012, r = 0.978 for end-diastolic and end-systolic volumes combined) already after the first run and the entry of 19 ± 3 points. In conclusion, KBR provided accurate measurement of the RV volume and EF with minimal user input. KBR is a clinically feasible alternative to full manual tracing of the heart borders from imaging data.
AB - We tested the accuracy and reproducibility of knowledge-based reconstruction (KBR) for measuring right ventricular (RV) volume and function. KBR enables rapid assessment of the right ventricle from sparse user input by referencing a database. KBR generates a 3-dimensional surface to fit points that the user enters at anatomic landmarks. We measured the RV volume using KBR from magnetic resonance images in 20 patients with repaired tetralogy of Fallot at end-diastole and end-systole. We entered points in the long- and short-axis and/or oblique views. The true volume was computed by manually tracing the RV borders for 3-dimensional reconstruction using the piecewise smooth subdivision surface method. The reference database included 54 patients with tetralogy of Fallot patients. The KBR values agreed closely with the true values for the end-diastolic volume (r = 0.993), end-systolic volume (r = 0.992), and ejection fraction (EF; r = 0.930). KBR slightly overestimated the end-diastolic volume (4 ± 10 ml, p = NS), end-systolic volume (1 ± 9 ml, p = NS), and EF (4 ± 3%, p = NS). No bias in the error was found by Bland-Altman analysis (p = NS for end-diastolic and end-systolic volume and EF). The KBR volumes had approached the true volumes (235 ± 93 vs 243 ± 93, p = 0.012, r = 0.978 for end-diastolic and end-systolic volumes combined) already after the first run and the entry of 19 ± 3 points. In conclusion, KBR provided accurate measurement of the RV volume and EF with minimal user input. KBR is a clinically feasible alternative to full manual tracing of the heart borders from imaging data.
UR - http://www.scopus.com/inward/record.url?scp=77949567270&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949567270&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2009.11.032
DO - 10.1016/j.amjcard.2009.11.032
M3 - Article
C2 - 20346319
AN - SCOPUS:77949567270
SN - 0002-9149
VL - 105
SP - 993
EP - 999
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 7
ER -