TY - JOUR
T1 - Acoustic droplet vaporization and propulsion of perfluorocarbon-loaded microbullets for targeted tissue penetration and deformation
AU - Kagan, Daniel
AU - Benchimol, Michael J.
AU - Claussen, Jonathan C.
AU - Chuluun-Erdene, Erdembileg
AU - Esener, Sadik
AU - Wang, Joseph
PY - 2012/7/23
Y1 - 2012/7/23
N2 - Bullets and rockets: Ultrasound-triggered vaporization of a perfluorocarbon compound loaded into microbullets provides the necessary force for the microbullets to penetrate, cleave, and deform cellular tissue for potential targeted drug delivery and precision nanosurgery. The microbullets have an inner Au layer that allows conjugation of a monolayer of thiolated cysteamine (green in picture) for electrostatic attachment of perfluorocarbon droplets (purple droplets).
AB - Bullets and rockets: Ultrasound-triggered vaporization of a perfluorocarbon compound loaded into microbullets provides the necessary force for the microbullets to penetrate, cleave, and deform cellular tissue for potential targeted drug delivery and precision nanosurgery. The microbullets have an inner Au layer that allows conjugation of a monolayer of thiolated cysteamine (green in picture) for electrostatic attachment of perfluorocarbon droplets (purple droplets).
KW - drug delivery
KW - electrostatic interactions
KW - perfluorinated solvents
KW - ultrasound
KW - vaporization
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U2 - 10.1002/anie.201201902
DO - 10.1002/anie.201201902
M3 - Article
C2 - 22692791
AN - SCOPUS:84864193487
SN - 1433-7851
VL - 51
SP - 7519
EP - 7522
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 30
ER -