Acromegaly and zollinger-euison syndrome secondary to an islet cell tumor: Characterization and quantification of plasma and tumor human growth hormone-releasing factor

Darrell M. Wilson; Gian Paolo Ceda; David G. Bostwick; Robert J. Webber; Jerome R. Minkoff; Allan Pont; Raymond L. Hintz; Klaus G. Bensch; Ron G. Rosenfeld; Andrew R. Hoffman

doi:10.1210/jcem-59-5-1002

Acromegaly and zollinger-euison syndrome secondary to an islet cell tumor: Characterization and quantification of plasma and tumor human growth hormone-releasing factor

Darrell M. Wilson, Gian Paolo Ceda, David G. Bostwick, Robert J. Webber, Jerome R. Minkoff, Allan Pont, Raymond L. Hintz, Klaus G. Bensch, Ron G. Rosenfeld, Andrew R. Hoffman

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

A young woman with acromegaly and Zollinger-Ellison syndrome associated with a GH-releasing factor (GRF)-and gastrin-secreting metastatic islet cell carcinoma was studied by means of specific antisera which recognize various regions of the GRF molecule. Using specific immunohistochemical techniques, the tumor cells were shown to contain GRF, gastrin, and gastrin-releasing peptide, but not GH. During a 4-h period, plasma GRF levels averaged 5.6 ± 1.4 ng/ml (±SD), while GH levels averaged 148 ± 71 ng/ml. GH secretion was pulsatile and increased after TRH administration. GRF RIAs may be useful in establishing the diagnosis of acromegaly secondary to the ectopic secretion of GRF.

Original language	English (US)
Pages (from-to)	1002-1005
Number of pages	4
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	59
Issue number	5
DOIs	https://doi.org/10.1210/jcem-59-5-1002
State	Published - Nov 1984
Externally published	Yes

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Biochemistry
Endocrinology
Clinical Biochemistry
Biochemistry, medical

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10.1210/jcem-59-5-1002

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Wilson, D. M., Ceda, G. P., Bostwick, D. G., Webber, R. J., Minkoff, J. R., Pont, A., Hintz, R. L., Bensch, K. G., Rosenfeld, R. G., & Hoffman, A. R. (1984). Acromegaly and zollinger-euison syndrome secondary to an islet cell tumor: Characterization and quantification of plasma and tumor human growth hormone-releasing factor. Journal of Clinical Endocrinology and Metabolism, 59(5), 1002-1005. https://doi.org/10.1210/jcem-59-5-1002

Acromegaly and zollinger-euison syndrome secondary to an islet cell tumor: Characterization and quantification of plasma and tumor human growth hormone-releasing factor. / Wilson, Darrell M.; Ceda, Gian Paolo; Bostwick, David G. et al.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 59, No. 5, 11.1984, p. 1002-1005.

Research output: Contribution to journal › Article › peer-review

Wilson, DM, Ceda, GP, Bostwick, DG, Webber, RJ, Minkoff, JR, Pont, A, Hintz, RL, Bensch, KG, Rosenfeld, RG & Hoffman, AR 1984, 'Acromegaly and zollinger-euison syndrome secondary to an islet cell tumor: Characterization and quantification of plasma and tumor human growth hormone-releasing factor', Journal of Clinical Endocrinology and Metabolism, vol. 59, no. 5, pp. 1002-1005. https://doi.org/10.1210/jcem-59-5-1002

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title = "Acromegaly and zollinger-euison syndrome secondary to an islet cell tumor: Characterization and quantification of plasma and tumor human growth hormone-releasing factor",

abstract = "A young woman with acromegaly and Zollinger-Ellison syndrome associated with a GH-releasing factor (GRF)-and gastrin-secreting metastatic islet cell carcinoma was studied by means of specific antisera which recognize various regions of the GRF molecule. Using specific immunohistochemical techniques, the tumor cells were shown to contain GRF, gastrin, and gastrin-releasing peptide, but not GH. During a 4-h period, plasma GRF levels averaged 5.6 ± 1.4 ng/ml (±SD), while GH levels averaged 148 ± 71 ng/ml. GH secretion was pulsatile and increased after TRH administration. GRF RIAs may be useful in establishing the diagnosis of acromegaly secondary to the ectopic secretion of GRF.",

author = "Wilson, {Darrell M.} and Ceda, {Gian Paolo} and Bostwick, {David G.} and Webber, {Robert J.} and Minkoff, {Jerome R.} and Allan Pont and Hintz, {Raymond L.} and Bensch, {Klaus G.} and Rosenfeld, {Ron G.} and Hoffman, {Andrew R.}",

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doi = "10.1210/jcem-59-5-1002",

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AU - Wilson, Darrell M.

AU - Ceda, Gian Paolo

AU - Bostwick, David G.

AU - Webber, Robert J.

AU - Minkoff, Jerome R.

AU - Pont, Allan

AU - Hintz, Raymond L.

AU - Bensch, Klaus G.

AU - Rosenfeld, Ron G.

AU - Hoffman, Andrew R.

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AB - A young woman with acromegaly and Zollinger-Ellison syndrome associated with a GH-releasing factor (GRF)-and gastrin-secreting metastatic islet cell carcinoma was studied by means of specific antisera which recognize various regions of the GRF molecule. Using specific immunohistochemical techniques, the tumor cells were shown to contain GRF, gastrin, and gastrin-releasing peptide, but not GH. During a 4-h period, plasma GRF levels averaged 5.6 ± 1.4 ng/ml (±SD), while GH levels averaged 148 ± 71 ng/ml. GH secretion was pulsatile and increased after TRH administration. GRF RIAs may be useful in establishing the diagnosis of acromegaly secondary to the ectopic secretion of GRF.

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Acromegaly and zollinger-euison syndrome secondary to an islet cell tumor: Characterization and quantification of plasma and tumor human growth hormone-releasing factor

Abstract

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