Activated protein C resistance in ischemic stroke not due to factor V arginine506→glutamine mutation

Mark Fisher, José A. Fernández, Sebastian F. Ameriso, Dangci Xie, Andras Gruber, Annlia Paganini-Hill, John H. Griffin

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


Background and Purpose: Resistance to activated protein C (APC), a natural plasma anticoagulant, is the most common identifiable risk factor for venous thromboembolic disease. One point mutation in coagulation factor V that renders it APC-resistant is found in >90% of APC-resistant venous thrombosis patients. To determine the prevalence of APC resistance and of this factor V mutation in stroke, we screened a group of ischemic stroke patients. Methods: Hispanic ischemic stroke patients were screened using two different activated partial thromboplastin time-based assays. One assay using neat patient plasma determined APC resistance, and the other assay using patient plasma diluted into factor V-deficient plasma determined APC- resistant factor V, including the Arg506→Gln mutation. Results: were compared with those in 31 Hispanic control subjects of similar ages. Results: Six of 63 (9.5%) stroke patients had APC resistance compared with none of 31 (0%) control subjects. No patient or control subject had APC-resistant factor V, ie, the factor V Arg506→Gln mutation. Conclusions: In Hispanic patients with ischemic stroke, the incidence (approximately 10%) of APC resistance is not caused by the factor V Arg506→Gln mutation. APC resistance not caused by this factor V mutation may be a risk factor for ischemic stroke in this population.

Original languageEnglish (US)
Pages (from-to)1163-1166
Number of pages4
Issue number7
StatePublished - Jul 1996
Externally publishedYes


  • Hispanic Americans
  • cerebral ischemia
  • protein C
  • thrombosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing


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