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Acute dasatinib exposure commits Bcr-Abl-dependent cells to apoptosis
Jennifer L. Snead
, Thomas O'Hare
, Lauren T. Adrian
, Christopher A. Eide
, Thoralf Lange
,
Brian J. Druker
, Michael W. Deininger
Knight Cancer Institute
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Contribution to journal
›
Article
›
peer-review
57
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Keyphrases
Apoptosis
100%
BCR-ABL
100%
Dasatinib
100%
Chronic Myeloid Leukemia
33%
Imatinib
16%
Clinical Efficacy
16%
In Vitro Assay
16%
Cell Death
16%
Apoptotic Cell Death
16%
Plasma Half-life
16%
Progenitor Cells
16%
Kinase Inhibitor
16%
Leukemia Cell Lines
16%
Acute Treatment
16%
Drug Development
16%
Apoptosis Induction
16%
Therapeutic Implications
16%
Leukemia Patients
16%
Nilotinib
16%
Once-daily Dosing
16%
In Vivo Pharmacokinetics
16%
Clonogenic Cells
16%
Targeted Inhibition
16%
Chronic Myeloid Leukaemia Cells
16%
Immunology and Microbiology
Programmed Cell Death
100%
Myeloid
66%
Pharmacokinetics
33%
Cell Death
33%
Plasma Half Life
33%
Chronic Myeloid Leukemia Cell Line
33%
In Vitro
33%
Phosphotransferase
33%
Kinase
33%
Pharmacology, Toxicology and Pharmaceutical Science
Dasatinib
100%
Chronic Myeloid Leukemia
50%
Imatinib
25%
Phosphotransferase Inhibitor
25%
Drug Development
25%
Myeloid Leukemia
25%
Nilotinib
25%
Pharmacokinetics
25%
Diseases
25%