TY - JOUR
T1 - Acute myeloid leukemia developing in a granulocyte colony-stimulating factor-mobilized stem cell donor
T2 - A case report and review of the literature
AU - Haddad, Housam
AU - Wungjiranirun, Manida
AU - Gergis, Usama
N1 - Publisher Copyright:
© 2015 King Faisal Specialist Hospital & Research Centre
PY - 2016
Y1 - 2016
N2 - We describe the first case of a FLT-3 mutated AML in a healthy donor, 3 years after recombinant human granulocyte colony stimulating factor (rhG-CSF)-mobilized peripheral blood stem cell (PBSC) harvest. The patient had a myeloablative (MA) matched unrelated donor (MUD) stem cell transplant (SCT) for refractory AML. However, he experienced a secondary graft failure. He had a second non myeloablative (NMA) on day +75 from a second MUD. He achieved a complete neutrophil and platelet engraftment. After 4 years of follow up, he is alive in complete remission with full second donor chimerism.
AB - We describe the first case of a FLT-3 mutated AML in a healthy donor, 3 years after recombinant human granulocyte colony stimulating factor (rhG-CSF)-mobilized peripheral blood stem cell (PBSC) harvest. The patient had a myeloablative (MA) matched unrelated donor (MUD) stem cell transplant (SCT) for refractory AML. However, he experienced a secondary graft failure. He had a second non myeloablative (NMA) on day +75 from a second MUD. He achieved a complete neutrophil and platelet engraftment. After 4 years of follow up, he is alive in complete remission with full second donor chimerism.
KW - Filgrastim
KW - Peripheral blood stem cell
KW - Recombinant human granulocyte colony-stimulating factor
KW - Stem cell donor
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U2 - 10.1016/j.hemonc.2015.06.001
DO - 10.1016/j.hemonc.2015.06.001
M3 - Article
C2 - 26173032
AN - SCOPUS:84995960733
SN - 1658-3876
VL - 9
SP - 123
EP - 125
JO - Hematology/ Oncology and Stem Cell Therapy
JF - Hematology/ Oncology and Stem Cell Therapy
IS - 3
ER -