TY - JOUR
T1 - Acute reversible lens opacity
T2 - Caused by drugs, cold, anoxia, asphyxia, stress, death and dehydration
AU - Fraunfelder, F. T.
AU - Burns, R. P.
N1 - Funding Information:
The assistance of Mrs L. Willenberg and Miss R,. Warren and the advice from Dr Calvin Hanna is gratefully acknowledged. This work was supported in part by U.S. Public Health Training Grant NB-5042-10, NB-10041-432 ant] Service Grant NB0-4770-03 from the National Institute of Neurological Diseases and Blindness, U.S. Public tIea lth Service.
PY - 1970/7
Y1 - 1970/7
N2 - Acute experimental lens opacities reported to be caused by narcotics, phenothiazines, epinephrine, anoxia, and certain types of lens opacities induced by death, asphyxia, cold or stress are prevented by closure of the animal's eyelids. An unawareness of the importance of eyelid position has led to confusion concerning the pathogenesis of many of these lens changes. Most of these experimental cataracts can be classified into a single group with common characteristics, for which we propose the term "acute reversible lens opacity". The opacity is a reversible loss of transparency of the superficial anterior lens cortex which is prevented by closure of the eyelids. This type of cataract may be produced by mechanical methods or agents which interfere with lid closure or depress the blink reflex. The lens opacity may regress even though the initiating stimulus is maintained. Although dehydration of the aqueous humor and lens is the most important factor in development of the lens transparency change, there are other factors which also play a role.
AB - Acute experimental lens opacities reported to be caused by narcotics, phenothiazines, epinephrine, anoxia, and certain types of lens opacities induced by death, asphyxia, cold or stress are prevented by closure of the animal's eyelids. An unawareness of the importance of eyelid position has led to confusion concerning the pathogenesis of many of these lens changes. Most of these experimental cataracts can be classified into a single group with common characteristics, for which we propose the term "acute reversible lens opacity". The opacity is a reversible loss of transparency of the superficial anterior lens cortex which is prevented by closure of the eyelids. This type of cataract may be produced by mechanical methods or agents which interfere with lid closure or depress the blink reflex. The lens opacity may regress even though the initiating stimulus is maintained. Although dehydration of the aqueous humor and lens is the most important factor in development of the lens transparency change, there are other factors which also play a role.
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U2 - 10.1016/S0014-4835(70)80005-7
DO - 10.1016/S0014-4835(70)80005-7
M3 - Article
C2 - 5456775
AN - SCOPUS:0014824782
SN - 0014-4835
VL - 10
SP - 19
EP - 30
JO - Experimental Eye Research
JF - Experimental Eye Research
IS - 1
ER -