Acute rheumatic fever: Clinical aspects and insights into pathogenesis and prevention

Judith A. Guzman-Cottrill, Preeti Jaggi, Stanford T. Shulman

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Acute rheumatic fever (ARF) is an inflammatory disease of childhood that occurs following untreated Group A streptococcal pharyngeal infections. Although it is well established that group A streptococcus is the sole etiologic agent of ARF, the pathogenesis and immune mechanisms are still not completely understood. We review the clinical manifestations, diagnostic, and therapeutic aspects of ARF. We also review recent advances in the understanding of disease pathogenesis, host susceptibility, and vaccine strategies to prevent group A streptococcal infection.

Original languageEnglish (US)
Pages (from-to)263-276
Number of pages14
JournalClinical and Applied Immunology Reviews
Issue number4
StatePublished - Jan 2004
Externally publishedYes


  • Acute rheumatic fever
  • Anti-streptococcal vaccine
  • M protein
  • Streptococcus pyogenes

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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