Adaptation of Bacillus subtilis to oxygen limitation

Michiko M. Nakano, F. Marion Hulett

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations


Bacillus subtilis grows anaerobically by at least two different pathways, respiration using nitrate as an electron acceptor and fermentation in the absence of electron acceptors. Regulatory mechanisms have evolved allowing cells to shift to these metabolic capabilities in response to changes in oxygen availability. These include transcriptional activation of fnr upon oxygen limitation, a process requiring the ResD-ResE two-component signal transduction system that also regulates aerobic respiration, FNR then activates transcription of other anaerobically induced genes including the narGHJI operon which encodes a respiratory nitrate reductase. Genes involved in fermentative growth are controlled by an unidentified FNR-independent regulatory pathway.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalFEMS Microbiology Letters
Issue number1
StatePublished - Dec 1 1997
Externally publishedYes


  • Anaerobic gene regulation
  • Bacillus subtilis
  • Fermentation
  • Nitrate respiration
  • Signal transduction

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics


Dive into the research topics of 'Adaptation of Bacillus subtilis to oxygen limitation'. Together they form a unique fingerprint.

Cite this