Adaptive optics optical coherence tomography for in vivo mouse retinal imaging

Yifan Jian, Robert J. Zawadzki, Marinko V. Sarunic

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Small animal models of retinal diseases are important to vision research, and noninvasive high resolution in vivo rodent retinal imaging is becoming an increasingly important tool used in this field. We present a custom Fourier domain optical coherence tomography (FD-OCT) instrument for high resolution imaging of mouse retina. In order to overcome aberrations in the mouse eye, we incorporated a commercial adaptive optics system into the sample arm of the refractive FD-OCT system. Additionally, a commercially available refraction canceling lens was used to reduce lower order aberrations and specular back-reflection from the cornea. Performance of the adaptive optics (AO) system for correcting residual wavefront aberration in the mice eyes is presented. Results of AO FD-OCT images of mouse retina acquired in vivo with and without AO correction are shown as well.

Original languageEnglish (US)
Article number056007
JournalJournal of biomedical optics
Issue number5
StatePublished - May 2013
Externally publishedYes


  • adaptive optics
  • mouse retina
  • optical coherence tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering


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