TY - JOUR
T1 - Adherence of candida albicans to tissues from mice with drug- or radiation- induced immunodeficiencies
AU - Mori, Motomi
PY - 1992/9
Y1 - 1992/9
N2 - Host factors that influence binding of Candida albicans to murine spleen, lymph node, and kidney were studied. Organs were harvested from BALB/cByJ and AKR/J mice immunocompromised by irradiation, cyclophosphamide, and cortisone acetate alone or in combination. Tissues from treated mice and untreated littermates were compared for their ability to bind C. albicans in ex vivo assays. Immunosuppressive regimens decreased yeast binding to splenic marginal zones, but when mice recovered for 5 days after treatment, adherence to spleen was similar to adherence in untreated littermates. Adherence to lymph node and kidney in treated mice was not different from binding to these tissues in untreated mice. Total serum immunoglobulin titers correlated with binding of yeast cells to mouse spleen. Blocking studies ruled out a mannosyl-fu- cosyl receptor-mediated binding. These results suggest that ex vivo adherence of C. albicans represents a host immune defense mechanism by which the immunocompetent host binds blood- borne yeast cells to host immune cells in reticuloendothelial organs to prevent dissemination to other organs.
AB - Host factors that influence binding of Candida albicans to murine spleen, lymph node, and kidney were studied. Organs were harvested from BALB/cByJ and AKR/J mice immunocompromised by irradiation, cyclophosphamide, and cortisone acetate alone or in combination. Tissues from treated mice and untreated littermates were compared for their ability to bind C. albicans in ex vivo assays. Immunosuppressive regimens decreased yeast binding to splenic marginal zones, but when mice recovered for 5 days after treatment, adherence to spleen was similar to adherence in untreated littermates. Adherence to lymph node and kidney in treated mice was not different from binding to these tissues in untreated mice. Total serum immunoglobulin titers correlated with binding of yeast cells to mouse spleen. Blocking studies ruled out a mannosyl-fu- cosyl receptor-mediated binding. These results suggest that ex vivo adherence of C. albicans represents a host immune defense mechanism by which the immunocompetent host binds blood- borne yeast cells to host immune cells in reticuloendothelial organs to prevent dissemination to other organs.
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U2 - 10.1093/infdis/166.3.587
DO - 10.1093/infdis/166.3.587
M3 - Article
C2 - 1500741
AN - SCOPUS:0026641132
SN - 0022-1899
VL - 166
SP - 587
EP - 597
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -