TY - JOUR
T1 - Adolescent novelty seeking is associated with greater ventral striatal and prefrontal brain response during evaluation of risk and reward
AU - Del Giacco, Amanda C.
AU - Jones, Scott A.
AU - Morales, Angelica M.
AU - Kliamovich, Dakota
AU - Nagel, Bonnie J.
N1 - Funding Information:
Dr. Nagel received funding from the National Institute on Alcohol Abuse and Alcoholism (R01 AA017664) and Dr. Morales received funding from the National Institute on Drug Abuse (K01 DA046649). This work was also supported by for the High Performance Computing Cluster, housed in OHSU’s Advanced Imaging Research Center (NIH S10OD018224).
Funding Information:
The authors acknowledge the participants and their families. AD acknowledges the OHSU Developmental Brain Imaging Lab research staff and laboratory, for their support. AD acknowledges the Advanced Imaging Research Center and their funding through the Oregon opportunity partnership for advancing biomedical research.
Funding Information:
The authors acknowledge the participants and their families. AD acknowledges the OHSU Developmental Brain Imaging Lab research staff and laboratory, for their support. AD acknowledges the Advanced Imaging Research Center and their funding through the Oregon opportunity partnership for advancing biomedical research.
Publisher Copyright:
© 2021, The Psychonomic Society, Inc.
PY - 2022/2
Y1 - 2022/2
N2 - Adolescence is a period during which reward sensitivity is heightened. Studies suggest that there are individual differences in adolescent reward-seeking behavior, attributable to a variety of factors, including temperament. This study investigated the neurobiological underpinnings of risk and reward evaluation as they relate to self-reported pleasure derived from novel experiences on the revised Early Adolescent Temperament Questionnaire (EATQ-R). Healthy participants (N = 265, ~50% male), aged 12-17 years, underwent functional magnetic resonance imaging during a modified Wheel of Fortune task, where they evaluated choices with varying probability of winning different monetary rewards. Across all participants, there was increased brain response in salience, reward, and cognitive control circuitry when evaluating choices with larger (compared with moderate) difference in risk/reward. Whole brain and a priori region-of-interest regression analyses revealed that individuals reporting higher novelty seeking had greater activation in bilateral ventral striatum, left middle frontal gyrus, and bilateral posterior cingulate cortex when evaluating the choices for largest difference in risk/reward. These novelty seeking associations with brain response were seen in the absence of temperament-related differences in decision-making behavior. Thus, while heightened novelty seeking in adolescents might be associated with greater neural sensitivity to risk/reward, accompanying increased activation in cognitive control regions might regulate reward-driven risk-taking behavior. More research is needed to determine whether individual differences in brain activation associated with novelty seeking are related to decision making in more ecologically valid settings.
AB - Adolescence is a period during which reward sensitivity is heightened. Studies suggest that there are individual differences in adolescent reward-seeking behavior, attributable to a variety of factors, including temperament. This study investigated the neurobiological underpinnings of risk and reward evaluation as they relate to self-reported pleasure derived from novel experiences on the revised Early Adolescent Temperament Questionnaire (EATQ-R). Healthy participants (N = 265, ~50% male), aged 12-17 years, underwent functional magnetic resonance imaging during a modified Wheel of Fortune task, where they evaluated choices with varying probability of winning different monetary rewards. Across all participants, there was increased brain response in salience, reward, and cognitive control circuitry when evaluating choices with larger (compared with moderate) difference in risk/reward. Whole brain and a priori region-of-interest regression analyses revealed that individuals reporting higher novelty seeking had greater activation in bilateral ventral striatum, left middle frontal gyrus, and bilateral posterior cingulate cortex when evaluating the choices for largest difference in risk/reward. These novelty seeking associations with brain response were seen in the absence of temperament-related differences in decision-making behavior. Thus, while heightened novelty seeking in adolescents might be associated with greater neural sensitivity to risk/reward, accompanying increased activation in cognitive control regions might regulate reward-driven risk-taking behavior. More research is needed to determine whether individual differences in brain activation associated with novelty seeking are related to decision making in more ecologically valid settings.
KW - Adolescence
KW - Individual differences
KW - Reward
KW - Risk-taking
KW - Temperament
KW - fMRI
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U2 - 10.3758/s13415-021-00937-2
DO - 10.3758/s13415-021-00937-2
M3 - Article
C2 - 34342865
AN - SCOPUS:85111833441
SN - 1530-7026
VL - 22
SP - 123
EP - 133
JO - Cognitive, Affective and Behavioral Neuroscience
JF - Cognitive, Affective and Behavioral Neuroscience
IS - 1
ER -